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Anti-Aggrecan Polyclonal Antibody 2
(Synonyms: PGCA, MSK16, CSPG1, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Cartilage-specific proteoglycan core protein, Aggrecan core protein 2, Aggrecan core protein, AGC1, ACAN) Copy Product Info
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Synonyms: PGCA, MSK16, CSPG1, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Cartilage-specific proteoglycan core protein, Aggrecan core protein 2, Aggrecan core protein, AGC1, ACAN
Catalog No. TMAB-00077 Copy Product Info
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Anti-Aggrecan Polyclonal Antibody 2 is a Rabbit antibody targeting Aggrecan. Anti-Aggrecan Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P.
Anti-Aggrecan Polyclonal Antibody 2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-Aggrecan Polyclonal Antibody 2 is a Rabbit antibody targeting Aggrecan. Anti-Aggrecan Polyclonal Antibody 2 can be used in IF,IHC-Fr,IHC-P. |
| Synonyms | PGCA, MSK16, CSPG1, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, Cartilage-specific proteoglycan core protein, Aggrecan core protein 2, Aggrecan core protein, AGC1, ACAN |
| Ig Type | IgG |
| Reactivity | Mouse,Rat (predicted:Human) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix. |
| Tissue Specificity | Restricted to cartilages. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS. |
| Immunogen | KLH conjugated synthetic peptide: human ACAN |
| Antigen Species | Human |
| Gene Name | ACAN |
| Gene ID | |
| Protein Name | Aggrecan core protein |
| Uniprot ID | |
| Biology Area | Aggrecan,Chondrogenesis |
| Function | Aggrecan has been detected in neural precursor cells (neurospheres; Kabos et al, 2004) During differentiation, neurospheres downregulate Chondroitin sulfate proteoglycans (CSPGs). Proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation; suggesting a link between CSPGs and CNS precursor biology. |
| Molecular Weight | Theoretical: 208/248 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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