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MAO-B-IN-49
Catalog No. T213591 Copy Product Info
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MAO-B-IN-49 is a selective, reversible MAO-B inhibitor with an IC50 of 1 nM for human MAO-B. It demonstrates significantly higher selectivity for MAO-B over MAO-A (IC50 = 633.9 nM). MAO-B-IN-49 reduces lipopolysaccharide (LPS)-induced ROS production in HT22 cells. It possesses notable neuroprotective properties and significantly improves motor dysfunction in MPTP-induced Parkinson's disease (PD) mouse models. MAO-B-IN-49 is applicable for Parkinson's disease research.
MAO-B-IN-49
Copy Product Info🥰Excellent
Catalog No. T213591
MAO-B-IN-49 is a selective, reversible MAO-B inhibitor with an IC50 of 1 nM for human MAO-B. It demonstrates significantly higher selectivity for MAO-B over MAO-A (IC50 = 633.9 nM). MAO-B-IN-49 reduces lipopolysaccharide (LPS)-induced ROS production in HT22 cells. It possesses notable neuroprotective properties and significantly improves motor dysfunction in MPTP-induced Parkinson's disease (PD) mouse models. MAO-B-IN-49 is applicable for Parkinson's disease research.
MAO-B-IN-49
Cas No. 3098883-91-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | MAO-B-IN-49 is a selective, reversible MAO-B inhibitor with an IC50 of 1 nM for human MAO-B. It demonstrates significantly higher selectivity for MAO-B over MAO-A (IC50 = 633.9 nM). MAO-B-IN-49 reduces lipopolysaccharide (LPS)-induced ROS production in HT22 cells. It possesses notable neuroprotective properties and significantly improves motor dysfunction in MPTP-induced Parkinson's disease (PD) mouse models. MAO-B-IN-49 is applicable for Parkinson's disease research. |
| In vitro | MAO-B-IN-49 (Compound ZM24) at concentrations of 2-50 μM over 24 hours results in more than 75% cell viability in HT22 cells under all tested conditions. Additionally, after co-incubating cells with varying drug concentrations of MAO-B-IN-49 (5-20 μM, 24 hours), there is a significant reduction in LPS-induced ROS generation in HT22 cells. |
| In vivo | MAO-B-IN-49, administered via intraperitoneal injection at doses of 10 mg/kg and 30 mg/kg once daily for 7 days, significantly ameliorates MPTP-induced motor dysfunction, including motor activity, coordination, and muscle strength, in mouse models of Parkinson's disease. |
| Molecular Weight | 362.38 |
| Formula | C19H20F2N2O3 |
| Cas No. | 3098883-91-8 |
| Smiles | [C@@H](C(N)=O)(C)N1CC=2C(=CC(OCC3=CC(F)=C(F)C=C3)=CC2)OCC1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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