proHB-EGF Protein, Human, Recombinant (His)

Name: proHB-EGF Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPJ-01286
Rating: 4.5 (1 reviews)

(Synonyms: proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor) Copy Product Info

Synonyms: proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor

Catalog No. TMPJ-01286 Copy Product Info

Heparin-binding EGF-like growth factor (HB-EGF) is a 1216 kDa member of the epidermal growth factor (EGF) family. It possesses an EGFlike domain, and a heparin-binding motif. Mature HBEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HBEGF shows 76% and 73% aa sequence identity with rat and mouse HBEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HBEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to nonmitogenic actions, while EGFR binding induces both mitogenic and nonmitogenic activity.

proHB-EGF Protein, Human, Recombinant (His)

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	7-10 days	7-10 days
10 µg	$60	7-10 days	7-10 days
20 µg	$86	7-10 days	7-10 days
50 µg	$141	7-10 days	7-10 days
100 µg	$227	7-10 days	7-10 days
200 µg	$368	7-10 days	7-10 days
500 µg	$713	7-10 days	7-10 days
1 mg	$1,020	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Heparin-binding EGF-like growth factor (HB-EGF) is a 1216 kDa member of the epidermal growth factor (EGF) family. It possesses an EGFlike domain, and a heparin-binding motif. Mature HBEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HBEGF shows 76% and 73% aa sequence identity with rat and mouse HBEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HBEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to nonmitogenic actions, while EGFR binding induces both mitogenic and nonmitogenic activity.
Species	Human
Expression System	HEK293 Cells
Tag	C-6xHis
Accession Number	Q99075
Amino Acid	Leu20-Leu148
Construction	Leu20-Leu148
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	proheparin-binding EGF-like growth factor, pro HB-EGF, heparin-binding epidermal growth factor, heparin-binding EGF-like growth factor, HEGFL, HB-EGF, DTSF, DTS, DTR, Diphtheria toxin receptor
Research Background	Heparin-binding EGF-like growth factor (HB-EGF) is a 1216 kDa member of the epidermal growth factor (EGF) family. It possesses an EGFlike domain, and a heparin-binding motif. Mature HBEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HBEGF shows 76% and 73% aa sequence identity with rat and mouse HBEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HBEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to nonmitogenic actions, while EGFR binding induces both mitogenic and nonmitogenic activity.

Chemical Properties

Molecular Weight

16-27 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.