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Eravacycline HCl

Name: Eravacycline HCl
Brand: TargetMol
SKU: T11227L1
Rating: 4.5 (1 reviews)

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Catalog No. T11227L1

Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)

Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.

Eravacycline HCl

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Purity: 95.30%

Catalog No. T11227L1Alias TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)

Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$285	Inquiry	Inquiry
5 mg	$686	Inquiry	Inquiry
10 mg	$998	Inquiry	Inquiry
25 mg	$1,480	Inquiry	Inquiry
50 mg	$1,990	Inquiry	Inquiry
100 mg	$2,690	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$947	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:95.30%

Appearance:Solid

Color:Yellow

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Eravacycline HCl (TP-434 HCl) is potent antibiotic with broad-spectrum antibacterial activity.
In vitro	Eravacycline is potent antibiotic against A. baumannii, including isolates that are resistant to sulbactam, meropenem/imipenem, levofloxacin, and tobramycin/amikacin. Eravacycline exhibits greater activity than the comparators of the tetracycline class, levofloxacin, amikacin, tobramycin, and colistin. The eravacycline MIC50/90 values are 0.5/1 mg/L[1].
In vivo	Eravacycline is active in multiple murine models of infection against clinically important Gram-negative and Gram-positive pathogens. Eravacycline is efficacious in mouse septicemia models, demonstrating 50% protective dose values of ≤1 mg/kg of body weight once a day (q.d.) against Staphylococcus aureus, including tetracycline-resistant isolates of methicillin-resistant S. aureus (MRSA), and Streptococcus pyogenes. The PD50s against Escherichia coli isolates are 1.2 to 4.4 mg/kg q.d[2].
Synonyms	TP-434 HCl, Eravacycline HCL(1207283-85-9 Free bse)

Chemical Properties

Molecular Weight	595.02
Formula	C₂₇H₃₂ClFN₄O₈
Smiles	O[C@]12[C@](C[C@@]3([H])C(C(C4=C(O)C(NC(CN5CCCC5)=O)=CC(F)=C4C3)=O)=C2O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (92.43 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6806 mL	8.4031 mL	16.8062 mL	84.0308 mL
5 mM	0.3361 mL	1.6806 mL	3.3612 mL	16.8062 mL
10 mM	0.1681 mL	0.8403 mL	1.6806 mL	8.4031 mL
20 mM	0.0840 mL	0.4202 mL	0.8403 mL	4.2015 mL
50 mM	0.0336 mL	0.1681 mL	0.3361 mL	1.6806 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc