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eCF506

Name: eCF506
Brand: TargetMol
SKU: T8499
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T8499Cas No. 1914078-41-3

eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)

eCF506

🥰Excellent

Purity: 98.16%

Catalog No. T8499Cas No. 1914078-41-3

eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)

Pack Size	Price	Availability
1 mg	$40	In Stock
2 mg	$57	In Stock
5 mg	$85	In Stock
10 mg	$126	In Stock
25 mg	$207	In Stock
50 mg	$369	In Stock
100 mg	$531	In Stock

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Batch Information

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Purity:98.16%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	eCF506 is a potent and selective inhibitor of SRC (IC50 < 0.5 nM)
Targets&IC50	Src:< 0.5 nM), MDA-MB-231 cells:9 nM (EC50), yes:2.1 nM
In vitro	eCF506 can inhibit tyrosine kinase Src with IC50 value less than 0.5 nM.
In vivo	METHODS: Immunodeficient Rag2-Il2rg double knockout mice were implanted with PX459v2 and ILK gRNA 2 tumors and then given bosutinib (75 mg/kg) or eCF506 (40 mg/kg) once daily by oral gavage, and tumor volume growth was observed. RESULTS eCF506 treatment completely blocked the growth of ILK gRNA and PX459v2 tumors in the mouse model. [2]

Chemical Properties

Molecular Weight	510.63
Formula	C₂₆H₃₈N₈O₃
Cas No.	1914078-41-3
Smiles	COc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
Relative Density.	1.29 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52.5 mg/mL (102.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9584 mL	9.7918 mL	19.5837 mL	97.9183 mL
5 mM	0.3917 mL	1.9584 mL	3.9167 mL	19.5837 mL
10 mM	0.1958 mL	0.9792 mL	1.9584 mL	9.7918 mL
20 mM	0.0979 mL	0.4896 mL	0.9792 mL	4.8959 mL
50 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9584 mL
100 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.9792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc