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Meclofenoxate hydrochloride

Name: Meclofenoxate hydrochloride
Brand: TargetMol
SKU: T1401
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1401Cas No. 3685-84-5

Alias Meclofenoxate HCl, Meclofenoxate (Centrophenoxine) HCl, Lucidril, Cerutil

Meclofenoxate hydrochloride (Lucidril) is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and mentally stimulating effect.

Meclofenoxate hydrochloride

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Purity: 97.05%

Catalog No. T1401Alias Meclofenoxate HCl, Meclofenoxate (Centrophenoxine) HCl, Lucidril, CerutilCas No. 3685-84-5

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$37	In Stock	In Stock
500 mg	$89	In Stock	In Stock
1 g	$128	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.05%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Meclofenoxate hydrochloride AI Summary

Meclofenoxate hydrochloride exhibits a wide range of bioactivities, including significant potency in inhibiting the proliferation of Plasmodium falciparum, and the expression/activity of various proteins such as Human Peripheral Myelin Protein 22, Bloom's syndrome helicase (BLM), histone lysine methyltransferase G9a, and TGF-b. It also inhibits delayed death in malarial parasites, polymerase Iota, and the entry of Marburg Virus into cells. The compound demonstrates growth inhibition in a variety of human tumor cell lines, including those from breast, lung, renal, colon, melanoma, ovarian, prostate, and leukemia. Additionally, it induces DNA re-replication in normal breast cells and colon adenocarcinoma cells. In OATP1B3 and OATP1B1 transfected CHO cells, Meclofenoxate hydrochloride shows significant inhibition of sodium fluorescein uptake, with inhibition rates of 88.3% and 70.12% at 10 µM, respectively. However, Meclofenoxate hydrochloride shows relatively low bioactivity against SARS-CoV-2, with an inhibition index of 0.1587 in Vero E6 cells and an inhibition rate of -0.03% in VERO-6 cells at 10 µM after 48 hours. It also inhibited SARS-CoV-2 induced cytotoxicity in Caco-2 cells by 18.01% at 10 µM after 48 hours and demonstrated minimal inhibition of the SARS-CoV-2 3CL-Pro protease by 9.156% at 20 µM using a FRET assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Meclofenoxate hydrochloride (Lucidril) is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and mentally stimulating effect.
Synonyms	Meclofenoxate HCl, Meclofenoxate (Centrophenoxine) HCl, Lucidril, Cerutil

Chemical Properties

Molecular Weight	294.17
Formula	C₁₂H₁₆ClNO₃·HCl
Cas No.	3685-84-5
Smiles	c1(ccc(cc1)Cl)OCC(=O)OCCN(C)C.Cl
Relative Density.	1.3255 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (203.96 mM), Sonication is recommended.

Ethanol: 54 mg/mL (183.57 mM), Sonication is recommended.

H2O: 53 mg/mL (180.17 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3994 mL	16.9970 mL	33.9939 mL	169.9697 mL
5 mM	0.6799 mL	3.3994 mL	6.7988 mL	33.9939 mL
10 mM	0.3399 mL	1.6997 mL	3.3994 mL	16.9970 mL
20 mM	0.1700 mL	0.8498 mL	1.6997 mL	8.4985 mL
50 mM	0.0680 mL	0.3399 mL	0.6799 mL	3.3994 mL
100 mM	0.0340 mL	0.1700 mL	0.3399 mL	1.6997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc