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GDP366

Name: GDP366
Brand: TargetMol
SKU: T11383
Price: 183 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11383Cas No. 501698-03-9

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells.

GDP366

🥰Excellent

Purity: 99.84%

Catalog No. T11383Cas No. 501698-03-9

GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells.

Pack Size	Price	Availability
1 mg	$183	In Stock
5 mg	$455	In Stock
10 mg	$690	In Stock
25 mg	$1,370	In Stock
50 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock

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Purity:99.84%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence, and mitotic catastrophe in human cancer cells.
In vitro	GDP366 induces polyploidy in multiple types of cancer cell lines. GDP366 decreass both the mRNA and protein levels of survivin and Op18. This inhibitory effect is not dependent on the status of p53 and p21 although GDP366 potently increases p53 and p21 levels. GDP366 significantly inhibits the growth of tumor cells in vitro and in vivo (nude mouse model) without rapid induction of apoptosis[1].

Chemical Properties

Molecular Weight	375.45
Formula	C₂₀H₁₇N₅OS
Cas No.	501698-03-9
Smiles	Cc1cccc(NC(=O)Nc2ccc(cc2)-c2csc3ncnc(N)c23)c1
Relative Density.	1.423 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (159.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6635 mL	13.3174 mL	26.6347 mL	133.1735 mL
5 mM	0.5327 mL	2.6635 mL	5.3269 mL	26.6347 mL
10 mM	0.2663 mL	1.3317 mL	2.6635 mL	13.3174 mL
20 mM	0.1332 mL	0.6659 mL	1.3317 mL	6.6587 mL
50 mM	0.0533 mL	0.2663 mL	0.5327 mL	2.6635 mL
100 mM	0.0266 mL	0.1332 mL	0.2663 mL	1.3317 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc