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XD14

Name: XD14
Brand: TargetMol
SKU: T19935
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19935Cas No. 1370888-71-3

XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).

XD14

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Purity: 97.46%

Catalog No. T19935Cas No. 1370888-71-3

XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$59	In Stock	In Stock
10 mg	$103	In Stock	In Stock
25 mg	$208	In Stock	In Stock
50 mg	$333	In Stock	In Stock
100 mg	$470	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.46%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

XD14 AI Summary

XD14 exhibits binding affinity to various bromodomain (BRD) proteins with the strongest affinities for BRD4 bromodomain 1 (Kd = 160-240 nM), BRD2 domain 1 (Kd = 170 nM), and BRD3 domain 1 (Kd = 380-2900 nM). It induces a change in melting temperature of 6.7 K for BRD4 bromodomain 1. XD14 also shows moderate to high bioactivity, including a growth inhibition effect on human HL60 cells with a GI value of 65.0% at 10 µM after 48 hours and a GI50 value of 17000.0 nM after 72 hours. Additionally, the compound demonstrates antiviral activity against SARS-CoV-2, inhibiting its cytotoxicity in Caco-2 cells by 28.12% at 10 µM after 48 hours and demonstrating 12.51% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. However, its inhibition of SARS-CoV-2 virus in VERO-6 cells is minimal at 0.09% after 48 hours at the same concentration. XD14 also exhibits weak inhibitory activity on the human HDAC6 enzyme, with inhibition percentages of -13.41% and -2.94% using different peptide substrates. Overall, XD14 shows promise in bromodomain inhibition and antiviral activity, with specific selectivity and binding affinity profiles..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	XD14 is an inhibitor of BET bromodomain (Kd of 160 nM, 170 nM, 380 nM, 490 nM, 830 nM and 850 nM for BRD4(1), BRD2(1), BRD3(1), BRD3(2), BRD2(2) and BRD4(2), respectively).
Targets&IC50	BRD3(1):380 nM (Kd), BRD2(1):170 nM (Kd), BRD4(2):850 nM (Kd), BRD3(2):490 nM (Kd), BRD2(2):830 nM (Kd), BRD4(1):160 nM (Kd)

Chemical Properties

Molecular Weight	421.51
Formula	C₂₀H₂₇N₃O₅S
Cas No.	1370888-71-3
Smiles	CCN(CC)S(=O)(=O)c1ccc(O)c(NC(=O)c2[nH]c(C)c(C(C)=O)c2CC)c1
Relative Density.	1.300 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.22 mg/mL (10.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3724 mL	11.8621 mL	23.7242 mL	118.6211 mL
5 mM	0.4745 mL	2.3724 mL	4.7448 mL	23.7242 mL
10 mM	0.2372 mL	1.1862 mL	2.3724 mL	11.8621 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc