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GRGDSP

Name: GRGDSP
Brand: TargetMol
SKU: TP1421
Rating: 4.5 (1 reviews)

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Catalog No. TP1421Cas No. 91037-75-1

GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is a linear RGD peptide and a fibronectin-derived peptide, and is also an effective integrin inhibitor, which can be used to modify the surface of cardiovascular implants to promote endothelialization.

GRGDSP

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Purity: 99.75%

Catalog No. TP1421Cas No. 91037-75-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	Inquiry	-	In Stock
100 mg	Inquiry	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:White

Resource Download

COA MS HPLC

Product Introduction

Bioactivity

Description	GRGDSP (Gly-Arg-Gly-Asp-Ser-Pro) is a linear RGD peptide and a fibronectin-derived peptide, and is also an effective integrin inhibitor, which can be used to modify the surface of cardiovascular implants to promote endothelialization.
In vitro	The effects of immobilized GRGDSP molecules on EC function were investigated under static and flow conditions at clearly defined GRGDSP surface densities (0–3 pmol/cm²). As the GRGDSP surface density increased, EC adhesion and migration progressively enhanced. Cell adhesion and migration on GRGDSP induced ERK activation, with a GRGDSP density of 0.2 pmol/cm² sufficient to activate ERK. [2]

Chemical Properties

Molecular Weight	587.58
Formula	C₂₂H₃₇N₉O₁₀
Cas No.	91037-75-1
Smiles	C([C@@H](NC([C@@H](NC(CNC([C@H](CCCNC(=N)N)NC(CN)=O)=O)=O)CC(O)=O)=O)CO)(=O)N1[C@H](C(O)=O)CCC1
Relative Density.	no data available
Sequence	Gly-Arg-Gly-Asp-Ser-Pro
Sequence Short	GRGDSP

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (136.15 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.7019 mL	8.5095 mL	17.0190 mL	85.0948 mL
5 mM	0.3404 mL	1.7019 mL	3.4038 mL	17.0190 mL
10 mM	0.1702 mL	0.8509 mL	1.7019 mL	8.5095 mL
20 mM	0.0851 mL	0.4255 mL	0.8509 mL	4.2547 mL
50 mM	0.0340 mL	0.1702 mL	0.3404 mL	1.7019 mL
100 mM	0.0170 mL	0.0851 mL	0.1702 mL	0.8509 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc