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Acebutolol hydrochloride

Name: Acebutolol hydrochloride
Brand: TargetMol
SKU: T1012
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1012Cas No. 34381-68-5

Alias Acebutolol HCl

Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.

Acebutolol hydrochloride

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Purity: 99.92%

Catalog No. T1012Alias Acebutolol HClCas No. 34381-68-5

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$42	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$61	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
In vitro	In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
In vivo	In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
Synonyms	Acebutolol HCl

Chemical Properties

Molecular Weight	372.89
Formula	C₁₈H₂₉ClN₂O₄
Cas No.	34381-68-5
Smiles	Cl.CCCC(=O)Nc1cc(C(=O)C)c(OCC(O)CNC(C)C)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 70 mg/mL (187.72 mM), Sonication is recommended.

H2O: 69 mg/mL (185.04 mM), Sonication is recommended.

DMSO: 250 mg/mL (670.44 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.36 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6818 mL	13.4088 mL	26.8176 mL	134.0878 mL
5 mM	0.5364 mL	2.6818 mL	5.3635 mL	26.8176 mL
10 mM	0.2682 mL	1.3409 mL	2.6818 mL	13.4088 mL
20 mM	0.1341 mL	0.6704 mL	1.3409 mL	6.7044 mL
50 mM	0.0536 mL	0.2682 mL	0.5364 mL	2.6818 mL
100 mM	0.0268 mL	0.1341 mL	0.2682 mL	1.3409 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc