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Acebutolol hydrochloride

🥰Excellent
Catalog No. T1012Cas No. 34381-68-5
Alias Acebutolol HCl

Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.

Acebutolol hydrochloride
Other Forms of Acebutolol hydrochloride:
AcebutololT2135937517-30-9
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Acebutolol hydrochloride

🥰Excellent
Purity: 99.92%
Catalog No. T1012Alias Acebutolol HClCas No. 34381-68-5
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$42In StockIn Stock
100 mg$48In StockIn Stock
200 mg$61In StockIn Stock
1 mL x 10 mM (in DMSO)$30In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.92%
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Product Introduction

Bioactivity
Description
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydrochloride salt form of acebutolol, a synthetic butyranilide derivative with hypotensive and antiarrhythmic activity. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol hydrochloride is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents.
In vitro
In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
In vivo
In J774 macrophages, Acebutolol (not bound to LDL) inhibited intracellular cholesteryl ester accumulation more strongly than oxenolol (bound to LDL) and Alprenolol.Acebutolol inhibited the uptake of NA by rat brain P2 fragments (IC50: 0.25 mM).CYP (125I-labeled) binds to human adipocyte membranes. The binding of CYP (125I-labeled) to human adipocyte membranes was inhibited by Acebutolol, and it replaced all specifically bound radioligands. 1 μM isoproterenol-induced lipolysis was completely inhibited by Acebutolol.
SynonymsAcebutolol HCl
Chemical Properties
Molecular Weight372.89
FormulaC18H29ClN2O4
Cas No.34381-68-5
SmilesCl.CCCC(=O)Nc1cc(C(=O)C)c(OCC(O)CNC(C)C)cc1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: 70 mg/mL (187.72 mM), Sonication is recommended.
H2O: 69 mg/mL (185.04 mM), Sonication is recommended.
DMSO: 50 mg/mL (134.09 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.36 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO/H2O/Ethanol
1mg5mg10mg50mg
1 mM2.6818 mL13.4088 mL26.8176 mL134.0878 mL
5 mM0.5364 mL2.6818 mL5.3635 mL26.8176 mL
10 mM0.2682 mL1.3409 mL2.6818 mL13.4088 mL
20 mM0.1341 mL0.6704 mL1.3409 mL6.7044 mL
50 mM0.0536 mL0.2682 mL0.5364 mL2.6818 mL
100 mM0.0268 mL0.1341 mL0.2682 mL1.3409 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

β-adrenergic receptorInhibitorinhibitBeta ReceptorAdrenergicReceptorAdrenergic ReceptorAcebutolol HydrochlorideAcebutolol hydrochlorideAcebutolol
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