Biricodar

Name: Biricodar
Brand: TargetMol
SKU: T14616
Rating: 4.5 (1 reviews)

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Catalog No. T14616Cas No. 159997-94-1

Alias VX-710

Biricodar is a P-glycoprotein and MRP-1 modulator.

Biricodar

😃Good

Catalog No. T14616Alias VX-710Cas No. 159997-94-1

Biricodar is a P-glycoprotein and MRP-1 modulator.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,820	8-10 weeks	8-10 weeks
50 mg	$2,380	8-10 weeks	8-10 weeks
100 mg	$3,100	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Biricodar is a P-glycoprotein and MRP-1 modulator.
In vitro	Biricodar demonstrates activity against P-glycoprotein (Pgp) and MRP-1 by increasing drug uptake and retention, reversing drug resistance mediated by wild-type BCRP (BCRPR482), and enhancing uptake, retention, and cytotoxicity in HL60/Adr (MRP-1) and 8226/MR20 cells (BCRP(R482)), while having minimal effect on MCF7 AdVP3000 cells (BCRP(R482T))[1]. It effectively inhibits photoaffinity labeling of P-glycoprotein by [3H]azidopine or [125I]iodoaryl azido-prazosin, with EC50 values of 0.75 and 0.55 μM[3]. In 8226/Dox6 cells (Pgp), biricodar enhances mitoxantrone and daunorubicin uptake by 55% and 100%, respectively, retention by 100% and 60%, respectively, and cytotoxicity by 3.1- and 6.9-fold, respectively. VX-710, a non-macrocyclic pipecolinate derivative that binds the FK506 receptor protein, has been shown to restore sensitivity in a range of multidrug-resistant cells, including myeloma, melanoma, carcinoma, and leukemia[2].
Synonyms	VX-710

Chemical Properties

Molecular Weight	603.71
Formula	C₃₄H₄₁N₃O₇
Cas No.	159997-94-1
Relative Density.	1.195 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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