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Dersalazine

Catalog No. T70084 CAS 188913-58-8

Synonyms: Dersalazine Free Base

Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.

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Dersalazine, CAS 188913-58-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 210.00
5 mg	In stock	$ 520.00
10 mg	In stock	$ 753.00
25 mg	In stock	$ 1,160.00
50 mg	In stock	$ 1,570.00
100 mg	In stock	$ 2,120.00
500 mg	In stock	$ 4,250.00

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Biological Description

Chemical Properties

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Description

In vivo

Dersalazine sodium (DS) (10 or 30 mg/kg; b.i.d.; rats), when administered for 7 days, showed intestinal anti-inflammatory effects in TNBS-induced colitis; these effects were observed both macroscopically and through the profile of inflammatory mediators (TNF, IL-1β, IL-6, and IL-17). Although the 2 day treatment with DS did not induce intestinal anti-inflammatory effects, it was sufficient to reduce the enhanced IL-17 expression. DS showed beneficial effects on DSS-induced colitis in C57BL/6 mice and reduced colonic pro-inflammatory cytokines IL-1β, IL-6, and IL-17.[2]

Synonyms	Dersalazine Free Base
Molecular Weight	600.67
Formula	C35H32N6O4
CAS No.	188913-58-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Pontes C, et al. Safety and activity of dersalazine sodium in patients with mild-to-moderate active colitis: double-blind randomized proof of concept study. Inflamm Bowel Dis. 2014;20(11):2004-2012. 2. Camuesco D, et al. The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012;165(3):729-740.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library

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Keywords

Dersalazine 188913-58-8 Immunology/Inflammation Others IL Receptor Platelet aggregation Dersalazine Free Base inhibitor inhibit

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