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Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody

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Catalog No. TMAC-00028

Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.

Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody

Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody

😃Good
Catalog No. TMAC-00028
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Pack SizePriceAvailabilityQuantity
50 μL$2167-10 days
100 μL$3167-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Ig Type
IgG
Reactivity
Human,Mouse,Rat,Monkey
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
AppearanceLiquid
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Research Backgroundfunction:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3.,
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human 53BP1 around the phosphorylation site of Ser6. AA range:1-50
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 213 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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