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Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
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Catalog No. TMAC-00028
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
😃Good
Catalog No. TMAC-00028
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $216 | 7-10 days | |
| 100 μL | $316 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat,Monkey |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Appearance | Liquid |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research Background | function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3., |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human 53BP1 around the phosphorylation site of Ser6. AA range:1-50 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 213 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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