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IM-156 acetate

Catalog No. T36420 CAS 2043654-54-0

Synonyms: HL271 acetate

IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPKα activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats .

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IM-156 acetate, CAS 2043654-54-0

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Biological Description

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Description	IM-156 acetate, an activator of NADH dehydrogenase (IC50=2.2 μM) and AMP-activated protein kinase alpha (AMPKα), is an orally available and bioavailable inhibitor of mitochondrial oxidative phosphorylation (OxPhos).IM-156 acetate increases AMPKα activity and inhibits chlorhexadiene-induced peritoneal fibrosis and inhibit tumor growth in rats .
Targets&IC50	OCR:3.3 µM, NADH dehydrogenase:2.2 µM
In vitro	IM-156 is an inhibitor of mitochondrial complex I, also known as an activator of NADH dehydrogenase (IC50 = 2.2 µM) and AMP-activated protein kinase α (AMPKα).[1][2]
In vivo	It reduces the oxygen consumption rate (OCR; IC50 = 3.3 µM) and decreases mitochondrial ATP production in Eµ-Myc mouse lymphoma cells.1 IM-156 (10, 30, and 50 µM) increases AMPKα activity in primary rat peritoneal mesothelial cells and protects against chlorhexidine-induced peritoneal fibrosis in rats when administered at a dose of 1 mg/kg.2 It reduces tumor growth in an AT-84 murine oral cancer model and decreases age-related decline in novel object recognition, spatial working, and contextual memory in mice.[3][4]

Synonyms	HL271 acetate
Molecular Weight	375.35
Formula	C15H20F3N5O3
CAS No.	2043654-54-0

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.0mg/mL (3.2mM)

DMF: 1.0mg/mL (3.2mM)

Ethanol: 1 mg/mL

References and Literature

1. Izreig S, et al. Repression of LKB1 by miR-17∼92 Sensitizes MYC-Dependent Lymphoma to Biguanide Treatment. Cell Rep Med. 2020;1(2):100014. 2. Ju KD, et al. HL156A, a novel AMP-activated protein kinase activator, is protective against peritoneal fibrosis in an in vivo and in vitro model of peritoneal fibrosis. Am J Physiol Renal Physiol. 2016;310(5):342-350. 3. Lam TG, et al. New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin-like growth factor/AKT/mammalian target of rapamycin pathways. Cancer Sci. 2018;109(3):699-709. 4. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018;27(1):45-56.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IM-156 acetate 2043654-54-0 HL271 Acetate IM-156 Acetate IM156 Acetate HL-271 Acetate IM 156 Acetate HL 271 Acetate HL271 acetate inhibitor inhibit

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