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Anti-CD59 Antibody (2A586)
😃Good
Catalog No. TMAC-00724
Alias MSK21, MIRL, MIN3, MIN2, MIN1, MIC11, MEM43, MAC-IP, MACIP, MACIF, HRF-20, HRF20, G344, CD59, 1F5
Anti-CD59 Antibody (2A586) is a Rabbit antibody targeting CD59. Anti-CD59 Antibody (2A586) can be used in WB,ICC/IF,FCM,IP.
Anti-CD59 Antibody (2A586)
Anti-CD59 Antibody (2A586)
😃Good
Catalog No. TMAC-00724Alias MSK21, MIRL, MIN3, MIN2, MIN1, MIC11, MEM43, MAC-IP, MACIP, MACIF, HRF-20, HRF20, G344, CD59, 1F5
Anti-CD59 Antibody (2A586) is a Rabbit antibody targeting CD59. Anti-CD59 Antibody (2A586) can be used in WB,ICC/IF,FCM,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $296 | 7-10 days | |
| 100 μL | $497 | 7-10 days |
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Chemical Properties
| Description | Anti-CD59 Antibody (2A586) is a Rabbit antibody targeting CD59. Anti-CD59 Antibody (2A586) can be used in WB,ICC/IF,FCM,IP. |
| Synonyms | MSK21, MIRL, MIN3, MIN2, MIN1, MIC11, MEM43, MAC-IP, MACIP, MACIF, HRF-20, HRF20, G344, CD59, 1F5 |
| Ig Type | IgG |
| Reactivity | Human |
| Verified Activity | 1. Western blot analysis of CD59 on different cells lysates using anti-CD59 antibody at 1/500 dilution. Positive control: Lane 1: Human placenta, Lane 2: HUVEC, Lane 3: K562. 2. ICC staining CD59 in HUVEC cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining CD59 in JAR cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. ICC staining CD59 in NIH-3T3 cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 5. Flow cytometric analysis of NIH-3T3 cells with CD59 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| Application | |
| Recommended Dose | WB: 1:1000-5000; ICC/IF: 1:100-500; IP: 1:10-50; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | CD59 is a GPI-anchored glycoprotein that is expressed on leukocytes, vascular endothelial cells, various epithelial cells and placenta. CD59 acts together with CD58 in mediating T cell adhesion and activation, and it may be a second ligand of CD2. CD59 functions as a regulator of the terminal pathway of complement by binding to the C8/C9 components of the assembling membrane attack complex (MAC) on host cell membranes, to stop the formation of the lytic pore. CD59 also drives both calcium release and activation of lipid-raft associated signalling molecules such as tyrosine kinases. CD59 gene has two p53-responsive domains that may be implicated in the defense of host cells from damage by the complement system in inflammation, suggesting that p53 could be used to mediate susceptibility of tumor cells to the complement lysis during chemotherapy. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 14/20 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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