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MS049 dihydrochloride
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Catalog No. T41292Cas No. 2095432-59-8
Alias MS-049 dihydrochloride
MS049 dihydrochloride is a selective and cell-active dual inhibitor of PRMT4 and PRMT6 (IC50=34/43 nM), capable of reducing Med12me2a and H3R2me2a levels in HEK293 cells.
MS049 dihydrochloride
😃Good
Catalog No. T41292Alias MS-049 dihydrochlorideCas No. 2095432-59-8
MS049 dihydrochloride is a selective and cell-active dual inhibitor of PRMT4 and PRMT6 (IC50=34/43 nM), capable of reducing Med12me2a and H3R2me2a levels in HEK293 cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $970 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS049 dihydrochloride is a selective and cell-active dual inhibitor of PRMT4 and PRMT6 (IC50=34/43 nM), capable of reducing Med12me2a and H3R2me2a levels in HEK293 cells. |
| Targets&IC50 | PRMT8:1600 nM, PRMT6:43 nM, PRMT4:34 nM |
| In vitro | MS049 dihydrochloride (0.1–10 μM; 20 h) concentration-dependently reduced H3R2me2a labeling in HEK293 cells [1]. MS049 dihydrochloride (0.1–100 μM; 72 h) concentration-dependently inhibited endogenous PRMT4 methyltransferase activity in HEK293 cells, resulting in reduced levels of asymmetric arginine dimethylation of Med12 [1]. |
| Synonyms | MS-049 dihydrochloride |
| Molecular Weight | 321.29 |
| Formula | C15H26Cl2N2O |
| Cas No. | 2095432-59-8 |
| Smiles | CNCCN(CC1)CCC1OCC2=CC=CC=C2.Cl.Cl |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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