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Tripelennamine hydrochloride

Name: Tripelennamine hydrochloride
Brand: TargetMol
SKU: T1269
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1269Cas No. 154-69-8

Alias Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HCl

Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.

Tripelennamine hydrochloride

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Purity: 99.81%

Catalog No. T1269Alias Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HClCas No. 154-69-8

Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.

Pack Size	Price	Availability
100 mg	$31	In Stock
500 mg	$98	In Stock
1 g	$142	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock

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Purity:99.81%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
Targets&IC50	H1 receptor:30 μM
In vitro	In equines, intravenous administration of Tripelennamine HCl (0.5 mg/kg) significantly elevates standing mixed venous blood oxygen tension and hemoglobin-O2 saturation while increasing oxygen content in both arterial and mixed venous blood, leading to central nervous system stimulation, resulting in heightened alertness and anxiety.
In vivo	In both human and rabbit liver microsomes, Tripelennamine inhibits the glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Synonyms	Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HCl

Chemical Properties

Molecular Weight	291.82
Formula	C₁₆H₂₁N₃·HCl
Cas No.	154-69-8
Smiles	Cl.CN(C)CCN(Cc1ccccc1)c1ccccn1
Relative Density.	1.20 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (171.34 mM), Sonication is recommended.

DMSO: 13 mg/mL (44.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4268 mL	17.1338 mL	34.2677 mL	171.3385 mL
5 mM	0.6854 mL	3.4268 mL	6.8535 mL	34.2677 mL
10 mM	0.3427 mL	1.7134 mL	3.4268 mL	17.1338 mL
20 mM	0.1713 mL	0.8567 mL	1.7134 mL	8.5669 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0685 mL	0.3427 mL	0.6854 mL	3.4268 mL
100 mM	0.0343 mL	0.1713 mL	0.3427 mL	1.7134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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