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Tripelennamine hydrochloride

Name: Tripelennamine hydrochloride
Brand: TargetMol
SKU: T1269
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1269Cas No. 154-69-8

Alias Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HCl

Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.

Tripelennamine hydrochloride

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Purity: 99.81%

Catalog No. T1269Alias Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HClCas No. 154-69-8

Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$34	In Stock	In Stock
500 mg	$64	-	In Stock
1 g	$98	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation.
Targets&IC50	H1 receptor:30 μM
In vitro	In equines, intravenous administration of Tripelennamine HCl (0.5 mg/kg) significantly elevates standing mixed venous blood oxygen tension and hemoglobin-O2 saturation while increasing oxygen content in both arterial and mixed venous blood, leading to central nervous system stimulation, resulting in heightened alertness and anxiety.
In vivo	In both human and rabbit liver microsomes, Tripelennamine inhibits the glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Synonyms	Tripelennamine HCl, Pyribenzamine hydrochloride, Pyribenzamine HCl

Chemical Properties

Molecular Weight	291.82
Formula	C₁₆H₂₁N₃·HCl
Cas No.	154-69-8
Smiles	Cl.CN(C)CCN(Cc1ccccc1)c1ccccn1
Relative Density.	1.20 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (171.34 mM), Sonication is recommended.

DMSO: 13 mg/mL (44.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.85 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.4268 mL	17.1338 mL	34.2677 mL	171.3385 mL
5 mM	0.6854 mL	3.4268 mL	6.8535 mL	34.2677 mL
10 mM	0.3427 mL	1.7134 mL	3.4268 mL	17.1338 mL
20 mM	0.1713 mL	0.8567 mL	1.7134 mL	8.5669 mL

H2O

	1mg	5mg	10mg	50mg
50 mM	0.0685 mL	0.3427 mL	0.6854 mL	3.4268 mL
100 mM	0.0343 mL	0.1713 mL	0.3427 mL	1.7134 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc