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Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) (Synonyms: interleukin 36, α, interleukin 36, alpha, IL36A, IL36 α/I...)

Name: Anti-IL-36 alpha/IL-1F6 Antibody (2Z319)
Brand: TargetMol
SKU: TMAY-01023
Rating: 4.5 (1 reviews)

Catalog No. TMAY-01023 Copy Product Info

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Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) is a Rabbit antibody targeting IL-36 alpha/IL-1F6. Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) can be used in ELISA.

Anti-IL-36 alpha/IL-1F6 Antibody (2Z319)

Copy Product Info

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Catalog No. TMAY-01023

Synonyms interleukin 36, α, interleukin 36, alpha, IL36A, IL36 α/IL-1F6, IL-1F6, IL1F6, IL1E, IL1(ε), IL1(EPSILON), FIL1E, FIL1(ε), FIL1(EPSILON), FIL1, FIL, 1E

Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) is a Rabbit antibody targeting IL-36 alpha/IL-1F6. Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) can be used in ELISA.

Anti-IL-36 alpha/IL-1F6 Antibody
(2Z319)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$269	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) is a Rabbit antibody targeting IL-36 alpha/IL-1F6. Anti-IL-36 alpha/IL-1F6 Antibody (2Z319) can be used in ELISA.
Synonyms	interleukin 36, α, interleukin 36, alpha, IL36A, IL36 α/IL-1F6, IL-1F6, IL1F6, IL1E, IL1(ε), IL1(EPSILON), FIL1E, FIL1(ε), FIL1(EPSILON), FIL1, FIL, 1E
Ig Type	Rabbit IgG
Clone	2Z319
Reactivity	Human
Specificity	Human IL-36 alpha/IL-1F6 No cross-reactivity in ELISA with Human IL1F5 Human IL1F7 Human IL1F8 Human IL1a Human IL1b
Application	ELISA
Recommended Dose	ELISA: 1:5000-1:10000
Antibody Type	Monoclonal
Host Species	Rabbit
Construction	This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-1F6 (rh IL-1F6; Q9UHA7Met1-Phe158).
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS
Research Background	Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine that plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Related Conjugates and Formulations

Conjucates

Unconjugated

Antigen Details

Immunogen	Recombinant Protein: Human IL-1F6 protein
Antigen Species	Human

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

FIL-1FIL 1

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