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PROTAC BET Degrader-14
Catalog No. T217062 Copy Product Info
🥰Excellent
PROTACBET Degrader-14 is a potent PROTAC compound designed to target BET (bromodomain and extraterminal domain) proteins. It effectively degrades all family members of BET, including BRD2, BRD3, and BRD4. The compound demonstrates significant efficacy in degrading BET proteins in the U2OS osteosarcoma cell line (BRD4 DC50 = 130 nM) and the KYSE180 esophageal squamous cell carcinoma cell line (DC50 = 40 nM). Its mechanism of degradation relies on the ubiquitin-proteasome system. Furthermore, PROTACBET Degrader-14 reduces the expression levels of BET-regulated gene products such as c-Myc, RUNX2, and KRT14, making it a valuable tool for osteosarcoma research.
PROTAC BET Degrader-14
Copy Product Info🥰Excellent
Catalog No. T217062
PROTACBET Degrader-14 is a potent PROTAC compound designed to target BET (bromodomain and extraterminal domain) proteins. It effectively degrades all family members of BET, including BRD2, BRD3, and BRD4. The compound demonstrates significant efficacy in degrading BET proteins in the U2OS osteosarcoma cell line (BRD4 DC50 = 130 nM) and the KYSE180 esophageal squamous cell carcinoma cell line (DC50 = 40 nM). Its mechanism of degradation relies on the ubiquitin-proteasome system. Furthermore, PROTACBET Degrader-14 reduces the expression levels of BET-regulated gene products such as c-Myc, RUNX2, and KRT14, making it a valuable tool for osteosarcoma research.
PROTAC BET Degrader-14
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | PROTACBET Degrader-14 is a potent PROTAC compound designed to target BET (bromodomain and extraterminal domain) proteins. It effectively degrades all family members of BET, including BRD2, BRD3, and BRD4. The compound demonstrates significant efficacy in degrading BET proteins in the U2OS osteosarcoma cell line (BRD4 DC50 = 130 nM) and the KYSE180 esophageal squamous cell carcinoma cell line (DC50 = 40 nM). Its mechanism of degradation relies on the ubiquitin-proteasome system. Furthermore, PROTACBET Degrader-14 reduces the expression levels of BET-regulated gene products such as c-Myc, RUNX2, and KRT14, making it a valuable tool for osteosarcoma research. |
| Targets&IC50 | BRD4:130 nM (DC50) |
| In vitro | PROTAC BET Degrader-14 (Compound 105B) exhibits a dose-dependent degradation of BRD4 in U2OS osteosarcoma cells at concentrations ranging from 0.01 to 10 μM over 24 hours. At 10 nM, it rapidly induces BRD4 degradation within 0 to 24 hours in U2OS cells, though this effect may rebound due to BRD4 resynthesis. Additionally, PROTAC BET Degrader-14 at concentrations of 0.01 nM to 1 μM for 24 hours reduces the expression levels of c-Myc and RUNX2 in U2OS osteosarcoma cells. In KYSE180 esophageal squamous cell carcinoma cells, concentrations from 0.51 nM to 10 μM lower the expression of KRT14 without degrading BRDT. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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