Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inhibits cancer cell migration and invasion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 190.00 | |
10 mg | In stock | $ 280.00 | |
25 mg | In stock | $ 480.00 | |
50 mg | In stock | $ 687.00 | |
100 mg | In stock | $ 998.00 | |
500 mg | In stock | $ 1,990.00 |
Description | AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inhibits cancer cell migration and invasion. |
Targets&IC50 | Axl:1.6 nM, PDGFRβ:2.3 nM (Kd) |
In vitro |
AXL-IN-13 (Compound 6li) inhibits Ba/F3-TEL-AXL cell proliferation with an IC50 of 4.7 nM (as determined by ELISA).[1] AXL-IN-13 (0-500 nM; 6 hours) inhibits AXL phosphorylation in MDA-MB-231 and 4T1 cells.[1] AXL-IN-13 also shows binding affinity for CSF1R, FLT1/3/4, KLT, PDGFRB, TIE2.[1] AXL-IN-13 (0-3 μM; 3 days) blocks TGF-β1 (10 ng/mL)-induced EMT in MDA-MB-231 cells.[1] AXL-IN-13 (0-3 μM; 24 hours) inhibits TGF-β1 (10 ng/mL)-induced migration and invasion of MDA-MB-231 cells.[1] |
In vivo |
AXL-IN-13 (Compound 6li) (50 or 100 mg/kg; p.o.; 14 days; Xenograft model derived from highly metastatic 4T1 cells) inhibits 4T1 tumor growth and metastasis.[1] AXL-IN-13 (25 mg/kg; oral; Xenograft model derived from highly metastatic 4T1 cells) shows a good PK curve, with an AUC of 8410.21 ng/mL/h, a T1/2 value of 4.22 h, and an oral bioavailability (F) of 14.4%.[1] |
Molecular Weight | 632.72 |
Formula | C34H41FN6O5 |
CAS No. | 2376928-82-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AXL-IN-13 2376928-82-2 Angiogenesis Stem Cells Tyrosine Kinase/Adaptors FLT TAM Receptor PDGFR TGF-beta/Smad inhibitor inhibit