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Aliskiren

Name: Aliskiren
Brand: TargetMol
SKU: T22233
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T22233Cas No. 173334-57-1

Alias SPP 100, CGP60536B, CGP 60536

Aliskiren (CGP 60536) is an orally active and potent renin inhibitor (IC50: 1.5 nM) with antihypertensive activity for the treatment of various cardiovascular diseases.

Aliskiren

🥰Excellent

Purity: 97.02%

Catalog No. T22233Alias SPP 100, CGP60536B, CGP 60536Cas No. 173334-57-1

Aliskiren (CGP 60536) is an orally active and potent renin inhibitor (IC50: 1.5 nM) with antihypertensive activity for the treatment of various cardiovascular diseases.

Pack Size	Price	Availability
1 mg	$30	In Stock
5 mg	$67	In Stock
10 mg	$107	In Stock
25 mg	$152	In Stock
50 mg	$197	In Stock
100 mg	$297	In Stock
200 mg	$442	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

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Batch Information

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Purity:97.02%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Aliskiren (CGP 60536) is an orally active and potent renin inhibitor (IC50: 1.5 nM) with antihypertensive activity for the treatment of various cardiovascular diseases.
Targets&IC50	renin:1.5 nM
In vitro	In BALB/c mice bearing C26 mouse colon carcinoma cells, a single intragastric administration of Aliskiren at 10 mg/kg significantly alleviates multiple cachexia-associated symptoms, including weight loss, tumor burden, muscle wasting, muscle dysfunction, and shortened survival[3].
Synonyms	SPP 100, CGP60536B, CGP 60536

Chemical Properties

Molecular Weight	551.76
Formula	C₃₀H₅₃N₃O₆
Cas No.	173334-57-1
Smiles	COCCCOc1cc(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)ccc1OC
Relative Density.	1.067 g/cm3 (Predicted)
Color	White
Appearance	Oil

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (144.99 mM), Sonication is recommended.

Ethanol: 80 mg/mL (144.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8124 mL	9.0619 mL	18.1238 mL	90.6191 mL
5 mM	0.3625 mL	1.8124 mL	3.6248 mL	18.1238 mL
10 mM	0.1812 mL	0.9062 mL	1.8124 mL	9.0619 mL
20 mM	0.0906 mL	0.4531 mL	0.9062 mL	4.5310 mL
50 mM	0.0362 mL	0.1812 mL	0.3625 mL	1.8124 mL
100 mM	0.0181 mL	0.0906 mL	0.1812 mL	0.9062 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc