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LFHP-1c

Name: LFHP-1c
Brand: TargetMol
SKU: T78141
Price: 689 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78141Cas No. 2102347-47-5

LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.

LFHP-1c

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Purity: 98.07%

Catalog No. T78141Cas No. 2102347-47-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$689	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.07%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.
In vitro	In primary rat brain microvascular endothelial cells (rBMECs), LFHP-1c (2 μmol/L; 1 hour) binds to PGAM5, facilitating the nuclear translocation of NRF2[1].
In vivo	In the nonhuman primate Macaca fascicularis model with tMCAO, LFHP-1c (3 mg/kg, 1 mL/kg; intravenous injection; at 4 h, 1, 2, 3, 4, 5, 6, and 7 days after tMCAO onset) reduced infarct volume, brain edema, and neurological deficits in the transient MCAO model in M. fascicularis[1].

Chemical Properties

Molecular Weight	873.13
Formula	C₅₅H₆₄N₆O₄
Cas No.	2102347-47-5
Smiles	O=C(OC(C=1C=CC=CC1C(=O)NCCCCCCCCNC(=O)C=2C=CC=CC2C=3C=CC(=CC3)CN4C5=CC(=CC(=C5N=C4CCC)C)C6=NC=7C=CC=CC7N6C)CCCC)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (91.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1453 mL	5.7265 mL	11.4530 mL	57.2652 mL
5 mM	0.2291 mL	1.1453 mL	2.2906 mL	11.4530 mL
10 mM	0.1145 mL	0.5727 mL	1.1453 mL	5.7265 mL
20 mM	0.0573 mL	0.2863 mL	0.5727 mL	2.8633 mL
50 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc