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LFHP-1c

Name: LFHP-1c
Brand: TargetMol
SKU: T78141
Rating: 4.5 (1 reviews)

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Catalog No. T78141Cas No. 2102347-47-5

LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.

LFHP-1c

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Purity: 98.07%

Catalog No. T78141Cas No. 2102347-47-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$689	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.07%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.
In vitro	In primary rat brain microvascular endothelial cells (rBMECs), LFHP-1c (2 μmol/L; 1 hour) binds to PGAM5, facilitating the nuclear translocation of NRF2[1].
In vivo	In the nonhuman primate Macaca fascicularis model with tMCAO, LFHP-1c (3 mg/kg, 1 mL/kg; intravenous injection; at 4 h, 1, 2, 3, 4, 5, 6, and 7 days after tMCAO onset) reduced infarct volume, brain edema, and neurological deficits in the transient MCAO model in M. fascicularis[1].

Chemical Properties

Molecular Weight	873.13
Formula	C₅₅H₆₄N₆O₄
Cas No.	2102347-47-5
Smiles	O=C(OC(C=1C=CC=CC1C(=O)NCCCCCCCCNC(=O)C=2C=CC=CC2C=3C=CC(=CC3)CN4C5=CC(=CC(=C5N=C4CCC)C)C6=NC=7C=CC=CC7N6C)CCCC)C

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (91.62 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.78 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1453 mL	5.7265 mL	11.4530 mL	57.2652 mL
5 mM	0.2291 mL	1.1453 mL	2.2906 mL	11.4530 mL
10 mM	0.1145 mL	0.5727 mL	1.1453 mL	5.7265 mL
20 mM	0.0573 mL	0.2863 mL	0.5727 mL	2.8633 mL
50 mM	0.0229 mL	0.1145 mL	0.2291 mL	1.1453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc