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Revefenacin

Name: Revefenacin
Brand: TargetMol
SKU: T7392
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7392Cas No. 864750-70-9

Alias TD-4208, GSK1160724

Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.

Revefenacin

🥰Excellent

Purity: 98.12%

Catalog No. T7392Alias TD-4208, GSK1160724Cas No. 864750-70-9

Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$147	In Stock
25 mg	$263	In Stock
50 mg	$396	In Stock
100 mg	$562	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock

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Purity:98.12%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.
Targets&IC50	M3 mAChR:0.18 Nm(ki)
In vivo	In anesthetized dogs, Revefenacin, along with tiotropium and glycopyrronium, produced sustained inhibition of acetylcholine-induced bronchoconstriction for up to 24 hours. In anesthetized rats, inhaled Revefenacin exhibited dose-dependent 24-hour bronchoprotection against methacholine-induced bronchoconstriction. The estimated 24-hour potency (expressed as concentration of dosing solution) was 45.0 μg/ml[1].
Synonyms	TD-4208, GSK1160724

Chemical Properties

Molecular Weight	597.75
Formula	C₃₅H₄₃N₅O₄
Cas No.	864750-70-9
Smiles	CN(CCN1CCC(CC1)OC(=O)Nc1ccccc1-c1ccccc1)C(=O)c1ccc(CN2CCC(CC2)C(N)=O)cc1
Relative Density.	1.26 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (209.12 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6729 mL	8.3647 mL	16.7294 mL	83.6470 mL
5 mM	0.3346 mL	1.6729 mL	3.3459 mL	16.7294 mL
10 mM	0.1673 mL	0.8365 mL	1.6729 mL	8.3647 mL
20 mM	0.0836 mL	0.4182 mL	0.8365 mL	4.1824 mL
50 mM	0.0335 mL	0.1673 mL	0.3346 mL	1.6729 mL
100 mM	0.0167 mL	0.0836 mL	0.1673 mL	0.8365 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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