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Poricoic acid A

Name: Poricoic acid A
Brand: TargetMol
SKU: T8181
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8181Cas No. 137551-38-3

Alias Poricoic acid A(F)

Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis.

Poricoic acid A

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Purity: 99.16%

Catalog No. T8181Alias Poricoic acid A(F)Cas No. 137551-38-3

Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$266	In Stock	In Stock
50 mg	$392	In Stock	In Stock
100 mg	$587	-	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.16%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Poricoic acid A AI Summary

Poricoic acid A exhibits notable bioactivities, including the inhibition of EBV-early antigen activation in human Raji cells, with increasing potency at lower molar ratios. It demonstrates a broad-spectrum anticancer activity, inhibiting the growth of various human tumor cell lines—such as renal, breast, non-small cell lung, leukemia, melanoma, ovarian, colon, prostate, and central nervous system cell lines—with a GI50 value of 15000.0 nM in the NCI60 assay. Specifically, it shows cytotoxic activity against human HL60 cells with an IC50 value of 38000.0 nM, although it does not exhibit significant cytotoxic effects on other cell lines, including CRL1579 cells, with an IC50 greater than 100000.0 nM. Furthermore, the compound also displays relatively weak antiproliferative activity against human K562, HL60, CCRF-CEM, and MOLT4 cells with IC50 values above 40000.0 nM in MTT assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Poricoic acid A (Poricoic acid A(F)) is a natural product with antitumor activity. It also enhances melatonin inhibition of AKI-to-CKD transition by regulating the Gas6/AxlNFκB/Nrf2 axis.
Synonyms	Poricoic acid A(F)

Chemical Properties

Molecular Weight	498.69
Formula	C₃₁H₄₆O₅
Cas No.	137551-38-3
Smiles	[H][C@]1([C@@H](CCC(=C)C(C)C)C(O)=O)[C@H](O)C[C@@]2(C)C3=CC[C@@H](C(C)=C)[C@](C)(CCC(O)=O)C3=CC[C@]12C
Relative Density.	1.11 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 108.89 mg/mL (218.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (4.01 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0053 mL	10.0263 mL	20.0525 mL	100.2627 mL
5 mM	0.4011 mL	2.0053 mL	4.0105 mL	20.0525 mL
10 mM	0.2005 mL	1.0026 mL	2.0053 mL	10.0263 mL
20 mM	0.1003 mL	0.5013 mL	1.0026 mL	5.0131 mL
50 mM	0.0401 mL	0.2005 mL	0.4011 mL	2.0053 mL
100 mM	0.0201 mL	0.1003 mL	0.2005 mL	1.0026 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc