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Parsaclisib

Name: Parsaclisib
Brand: TargetMol
SKU: T12367
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12367Cas No. 1426698-88-5

Alias INCB050465

Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)

Parsaclisib

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Purity: 98.59%

Catalog No. T12367Alias INCB050465Cas No. 1426698-88-5

Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$322	In Stock
10 mg	$522	In Stock
25 mg	$848	In Stock
50 mg	$1,170	In Stock
100 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$353	In Stock

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Batch Information

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Purity:98.59%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Targets&IC50	PI3Kδ:1 nM (at 1 mM ATP)
In vitro	Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50 < 10 nM)[1].
Synonyms	INCB050465

Chemical Properties

Molecular Weight	432.88
Formula	C₂₀H₂₂ClFN₆O₂
Cas No.	1426698-88-5
Smiles	CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122 mg/mL (281.83 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3101 mL	11.5505 mL	23.1011 mL	115.5055 mL
5 mM	0.4620 mL	2.3101 mL	4.6202 mL	23.1011 mL
10 mM	0.2310 mL	1.1551 mL	2.3101 mL	11.5505 mL
20 mM	0.1155 mL	0.5775 mL	1.1551 mL	5.7753 mL
50 mM	0.0462 mL	0.2310 mL	0.4620 mL	2.3101 mL
100 mM	0.0231 mL	0.1155 mL	0.2310 mL	1.1551 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc