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Sirt1/2-IN-2

Catalog No. T79563 CAS 670267-73-9

Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1].

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Sirt1/2-IN-2, CAS 670267-73-9

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Biological Description

Chemical Properties

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Description

In vitro

Sirt1/2-IN-2 (compound hsa55) at a concentration of 5 μM over 48 hours induces apoptosis in various tumor cell lines, with IC50 values of 13 μM for MV4-11, 11.5 μM for MOLM-13, 34.4 μM for THP1, and 27.5 μM for Jurkat cells [1]. Additionally, at 100 μM for 30 minutes, Sirt1/2-IN-2 reduces the thermal stability of SIRT1 and SIRT2 proteins at different temperatures. At concentrations of 25 μM and 30 μM over 24 hours, the compound increases the levels of acetylated p53 and α-tubulin in MOLM-13 cells [1].

Molecular Weight	398.46
Formula	C18H14N4O3S2
CAS No.	670267-73-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Related Products

Related compounds with same targets

SIRT1-IN-1 SIRT1 activator 1 N-Caffeoyltryptophan Thiomyristoyl Nicotinamide Riboside Triflate MC3482 MDL-800 Tenovin-3

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Keywords

Sirt1/2-IN-2 670267-73-9 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.