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Flesinoxan

Name: Flesinoxan
Brand: TargetMol
SKU: T16711
Rating: 4.5 (1 reviews)

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Catalog No. T16711Cas No. 98206-10-1

Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).

Flesinoxan

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Catalog No. T16711Cas No. 98206-10-1

Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$372	8-10 weeks	8-10 weeks
25 mg	$1,200	8-10 weeks	8-10 weeks
50 mg	$1,570	8-10 weeks	8-10 weeks
100 mg	$2,360	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$456	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
Targets&IC50	5-HT1A receptor:24 nM （EC50）
In vivo	Flesinoxan functions as a partial agonist at postsynaptic and a full agonist at presynaptic 5-HT1A receptors. Its intravenous delivery inhibits the activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons, bearing a similar antagonistic effect on 5-HT's influence on CA3 pyramidal neurons as 8-OH-DPAT. Studies of acute brain penetration revealed that nine minutes post-intravenous administration, [3H]8-OH-DPAT achieves significantly higher brain concentrations than [3H]Flesinoxan. Both Flesinoxan and 8-OH-DPAT, when administered subcutaneously, induce dose-dependent hypothermia, with Flesinoxan's effect being notably reduced by the pre-administration of pindolol, a non-selective 5-HT1A antagonist, and methysergide, a 5-HT1/2 antagonist. Comparable levels of hypothermia are observed with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT, though Flesinoxan's peak effect transpires 30 minutes later than that of 8-OH-DPAT and diminishes more gradually.

Chemical Properties

Molecular Weight	415.46
Formula	C₂₂H₂₆FN₃O₄
Cas No.	98206-10-1
Relative Density.	1.271g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31.25 mg/mL (75.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4070 mL	12.0349 mL	24.0697 mL	120.3485 mL
5 mM	0.4814 mL	2.4070 mL	4.8139 mL	24.0697 mL
10 mM	0.2407 mL	1.2035 mL	2.4070 mL	12.0349 mL
20 mM	0.1203 mL	0.6017 mL	1.2035 mL	6.0174 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc