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Flesinoxan

Name: Flesinoxan
Brand: TargetMol
SKU: T16711
Rating: 4.5 (1 reviews)

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Catalog No. T16711Cas No. 98206-10-1

Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).

Flesinoxan

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Catalog No. T16711Cas No. 98206-10-1

Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$372	8-10 weeks	8-10 weeks
25 mg	$1,200	8-10 weeks	8-10 weeks
50 mg	$1,570	8-10 weeks	8-10 weeks
100 mg	$2,360	8-10 weeks	8-10 weeks
1 mL x 10 mM (in DMSO)	$456	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Flesinoxan, a hypotensive agent, is an effective, high-affinity, and selective 5-hydroxytryptamine1A receptor agonist (EC50: 24 nM).
Targets&IC50	5-HT1A receptor:24 nM （EC50）
In vivo	Flesinoxan functions as a partial agonist at postsynaptic and a full agonist at presynaptic 5-HT1A receptors. Its intravenous delivery inhibits the activity of both CA3 pyramidal neurons and dorsal raphe 5-HT neurons, bearing a similar antagonistic effect on 5-HT's influence on CA3 pyramidal neurons as 8-OH-DPAT. Studies of acute brain penetration revealed that nine minutes post-intravenous administration, [3H]8-OH-DPAT achieves significantly higher brain concentrations than [3H]Flesinoxan. Both Flesinoxan and 8-OH-DPAT, when administered subcutaneously, induce dose-dependent hypothermia, with Flesinoxan's effect being notably reduced by the pre-administration of pindolol, a non-selective 5-HT1A antagonist, and methysergide, a 5-HT1/2 antagonist. Comparable levels of hypothermia are observed with 3 mg/kg of Flesinoxan and 0.5 mg/kg of 8-OH-DPAT, though Flesinoxan's peak effect transpires 30 minutes later than that of 8-OH-DPAT and diminishes more gradually.

Chemical Properties

Molecular Weight	415.46
Formula	C₂₂H₂₆FN₃O₄
Cas No.	98206-10-1
Smiles	OC[C@@H]1COc2c(O1)cccc2N1CCN(CCNC(=O)c2ccc(F)cc2)CC1
Relative Density.	1.271g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 31.25 mg/mL (75.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (4.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4070 mL	12.0349 mL	24.0697 mL	120.3485 mL
5 mM	0.4814 mL	2.4070 mL	4.8139 mL	24.0697 mL
10 mM	0.2407 mL	1.2035 mL	2.4070 mL	12.0349 mL
20 mM	0.1203 mL	0.6017 mL	1.2035 mL	6.0174 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4070 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc