9-Decyn-1-ol

Name: 9-Decyn-1-ol
Brand: TargetMol
SKU: T17346
Rating: 4.5 (1 reviews)

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Catalog No. T17346Cas No. 17643-36-6

9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in synthesizing PROTACs, acting as a conjugation agent to combine GDC-0068 and Lenalidomide to form INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].

9-Decyn-1-ol

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Catalog No. T17346Cas No. 17643-36-6

Pack Size	Price	Availability	Quantity
100 mg	Inquiry	7-10 days
500 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	9-Decyn-1-ol is an alkyl/ether-based PROTAC linker used in synthesizing PROTACs, acting as a conjugation agent to combine GDC-0068 and Lenalidomide to form INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].
In vitro	9-Decyn-1-ol facilitates the conjugation of GDC-0068 with Lenalidomide, producing INY-03-041. This compound is a comprehensive AKT degrader, formed through the linkage of the ATP-competitive AKT inhibitor GDC-0068 and Lenalidomide using a connector[1].

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	17643-36-6
Relative Density.	0.87

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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