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NSC 694621

Name: NSC 694621
Brand: TargetMol
SKU: T60018
Rating: 4.5 (1 reviews)

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Catalog No. T60018Cas No. 104857-29-6

NSC 694621 is a potent PCAF inhibitor with an IC50 of 5.71 μM (PCAF/H3 1-21) and demonstrates significant activity in inhibiting cancer cell proliferation, indicating potential as a new anticancer agent[1].

NSC 694621

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Catalog No. T60018Cas No. 104857-29-6

Pack Size	Price	Availability	Quantity
2 mg	$58	5 days

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Product Introduction

Bioactivity

Description	NSC 694621 is a potent PCAF inhibitor with an IC50 of 5.71 μM (PCAF/H3 1-21) and demonstrates significant activity in inhibiting cancer cell proliferation, indicating potential as a new anticancer agent[1].
In vitro	NSC 694621 (25 μM; 72 h) exhibits the effect of antiproliferative to SK-N-SH and HCT116 cells [1]. Cell Proliferation Assay [1] Cell Line: SK-N-SH, HCT116 cells Concentration: 25 μM Incubation Time: 72 h Result: Showed antiproliferative effect to SK-N-SH and HCT116 cells with GI 50 of 19.2 μM and growth inhibition of 29%, respectively.

Chemical Properties

Molecular Weight	258.3
Formula	C₁₃H₁₀N₂O₂S
Cas No.	104857-29-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NSC 694621NSC-694621NSC694621Isothiazolo[5,4 b]pyridin 3(2H) one, 2 (4 methoxyphenyl) Isothiazolo[5,4b]pyridin3(2H)one, 2(4methoxyphenyl)