Shopping Cart
Remove All
Your shopping cart is currently empty
NSC 694621
🥰Excellent
Catalog No. T60018Cas No. 104857-29-6
Alias NSC694621
NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.
NSC 694621
🥰Excellent
Purity: 99.7%
Catalog No. T60018Alias NSC694621Cas No. 104857-29-6
NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $53 | - | In Stock | |
| 5 mg | $85 | - | In Stock | |
| 10 mg | $133 | - | In Stock | |
| 25 mg | $218 | - | In Stock | |
| 50 mg | $325 | - | In Stock | |
| 100 mg | $483 | - | In Stock | |
| 200 mg | $691 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.7%
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
| Description | NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential. |
| Targets&IC50 | SK-N-SH neuroblastoma cells:19.2 ± 1.22 μM (GI₅₀), PCAF (HAT) H4 (2–24):1.59 μM, PCAF (HAT) H3 (1–21): 5.19 μM |
| In vitro | NSC 694621 inhibits PCAF HAT activity with an IC₅₀ of 5.19 μM for H3 and 1.59 μM for H4, showing stronger inhibition for H4[1]. NSC 694621 shows moderate antiproliferative effects, with a GI₅₀ of 19.2 ± 1.22 μM in SK-N-SH neuroblastoma cells. In HCT116 colorectal cancer cells, NSC 694621 inhibits growth by 29% at 25 μM[1]. |
| Synonyms | NSC694621 |
| Molecular Weight | 258.3 |
| Formula | C13H10N2O2S |
| Cas No. | 104857-29-6 |
| Smiles | O=C1C2=CC=CN=C2SN1C3=CC=C(OC)C=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.87 mM), Sonication and heating are recommended | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
| |||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy NSC 694621 | purchase NSC 694621 | NSC 694621 cost | order NSC 694621 | NSC 694621 chemical structure | NSC 694621 in vitro | NSC 694621 formula | NSC 694621 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.