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NSC 694621
🥰Excellent
Catalog No. T60018Cas No. 104857-29-6
Alias NSC694621
NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.
NSC 694621
🥰Excellent
Catalog No. T60018Alias NSC694621Cas No. 104857-29-6
NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $53 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $218 | In Stock | |
| 50 mg | $325 | In Stock | |
| 100 mg | $483 | In Stock | |
| 200 mg | $691 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential. |
| Targets&IC50 | PCAF (HAT) H3 (1–21): 5.19 μM, SK-N-SH neuroblastoma cells:19.2 ± 1.22 μM (GI₅₀), PCAF (HAT) H4 (2–24):1.59 μM |
| In vitro | NSC 694621 inhibits PCAF HAT activity with an IC₅₀ of 5.19 μM for H3 and 1.59 μM for H4, showing stronger inhibition for H4[1]. NSC 694621 shows moderate antiproliferative effects, with a GI₅₀ of 19.2 ± 1.22 μM in SK-N-SH neuroblastoma cells. In HCT116 colorectal cancer cells, NSC 694621 inhibits growth by 29% at 25 μM[1]. |
| Alias | NSC694621 |
| Molecular Weight | 258.3 |
| Formula | C13H10N2O2S |
| Cas No. | 104857-29-6 |
| Smiles | O=C1C2=CC=CN=C2SN1C3=CC=C(OC)C=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.87 mM), Sonication and heating are recommended | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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