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Anti-Sequestosome-1 Antibody (4X151) is a Mouse antibody targeting Sequestosome-1. Anti-Sequestosome-1 Antibody (4X151) can be used in ICC,IHC,FCM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $296 | 7-10 days | |
100 μL | $427 | 7-10 days |
Description | Anti-Sequestosome-1 Antibody (4X151) is a Mouse antibody targeting Sequestosome-1. Anti-Sequestosome-1 Antibody (4X151) can be used in ICC,IHC,FCM. |
Reactivity | Human,Mouse,Rat |
Application | |
Recommended Dose | WB: 1:500-1000; IHC: 1:200; ICC: 1:200; FCM: 1 μg per 1 x 106 cells |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | Hybridoma Monoclonal Antibody |
Purification | Peptide affinity purified. |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | Sequestosome 1 (SQSTM1, p62) is a ubiquitin binding protein involved in cell signaling, oxidative stress and autophagy. It was first identified as a protein that binds to the SH2 domain of p56Lck and independently found to interact with PKCζ. SQSTM1 was subsequently found to interact with ubiquitin, providing a scaffold for several signaling proteins and triggering degradation of proteins through the proteasome or lysosome. Interaction between SQSTM1 and TRAF6 leads to the K63-linked polyubiquitination of TRAF6 and subsequent activation of the NF-κB pathway. It may play a role in titin/TTN downstream signaling in muscle cells and regulate signaling cascades through ubiquitination. P62 may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. |
Conjucates | Unconjugated |
Immunogen | KLH conjugated synthetic peptide: within human SQSTM1 40-100 aa |
Antigen Species | human |
Uniprot ID |
Molecular Weight | Theoretical: 62 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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