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TDCPP

Name: TDCPP
Brand: TargetMol
SKU: T5879
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5879Cas No. 13674-87-8

Alias Tris(1,3-dichloroisopropyl)phosphate, Fyrol FR 2

TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.

TDCPP

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Purity: 99.97%

Catalog No. T5879Alias Tris(1,3-dichloroisopropyl)phosphate, Fyrol FR 2Cas No. 13674-87-8

TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$30	In Stock	In Stock
100 mg	$40	In Stock	In Stock
500 mg	$92	In Stock	In Stock
1 g	$133	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Oil

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.
In vitro	A dose-dependent decrease of cell viability after TDCPP exposure with LC50 at 202 μg/mL. A concentration-dependent apoptotic sign was observed in HCECs after exposing to ≥2 μg/mL TDCPP. Endoplasmic reticulum stress induction was evidenced by up-regulation of its biomarker genes (ATF-4, CHOP, BiP, and XBP1). Furthermore, alternation of Bcl-2/Bax expression, mitochondrial membrane potential loss, cellular ATP content decrease, and caspase-3 and -9 activity increase were observed after exposing to 2 or 20 μg/mL TDCPP. Implicated the involvement of endoplasmic reticulum stress in TDCPP-induced HCEC apoptosis, probably mediated by mitochondrial apoptotic pathway. TDCPP exposure induced toxicity to human cornea.
Cell Research	Human corneal epithelial cells (HCECs) were cultured in DMEM supplemented with 10% FBS, 10 ng/mL EGF, and 1% penicillin-streptomycin solution in an incubator with 5% CO2 at 37℃.?After reaching confluence, HCECs were replanted into 6/24/ 96-well plates or petri dishes with different initial densities and cultured for 24 h to reach ~70% confluence.?Then, TDCPP dissolved in n-hexane was solvent-exchanged to DMSO and serially diluted by DMEM to achieve concentrations from 0.034 to 340 μg/mL.?For cell exposure, the culture medium was aspirated and treated with TDCPP solutions (DMSO <0.1%) for 24 h with 0.1% DMSO solution as vehicle control[1].
Synonyms	Tris(1,3-dichloroisopropyl)phosphate, Fyrol FR 2

Chemical Properties

Molecular Weight	430.90
Formula	C₉H₁₅Cl₆O₄P
Cas No.	13674-87-8
Smiles	P(OC(CCl)CCl)(OC(CCl)CCl)(OC(CCl)CCl)=O
Relative Density.	1.512

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (139.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.64 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3207 mL	11.6036 mL	23.2072 mL	116.0362 mL
5 mM	0.4641 mL	2.3207 mL	4.6414 mL	23.2072 mL
10 mM	0.2321 mL	1.1604 mL	2.3207 mL	11.6036 mL
20 mM	0.1160 mL	0.5802 mL	1.1604 mL	5.8018 mL
50 mM	0.0464 mL	0.2321 mL	0.4641 mL	2.3207 mL
100 mM	0.0232 mL	0.1160 mL	0.2321 mL	1.1604 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc