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Enzalutamide-d3

Name: Enzalutamide-d3
Brand: TargetMol
SKU: T11208
Rating: 4.5 (1 reviews)

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Catalog No. T11208Cas No. 1443331-82-5

Alias MDV3100-d3, MDV3100 D3, Deutenzalutamide-d3

Enzalutamide-d3 (Deutenzalutamide-d3) is a deuterium-labeled form of the androgen receptor antagonist enzalutamide, retaining potent anti-androgen and antineoplastic activity with an IC50 of 36 nM in LNCaP prostate cancer cells, and is primarily used in pharmacokinetic, metabolic tracing, and drug interaction studies.

Enzalutamide-d3

😃Good

Catalog No. T11208Alias MDV3100-d3, MDV3100 D3, Deutenzalutamide-d3Cas No. 1443331-82-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$108	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Enzalutamide-d3 (Deutenzalutamide-d3) is a deuterium-labeled form of the androgen receptor antagonist enzalutamide, retaining potent anti-androgen and antineoplastic activity with an IC50 of 36 nM in LNCaP prostate cancer cells, and is primarily used in pharmacokinetic, metabolic tracing, and drug interaction studies.
Targets&IC50	Androgen receptor:21 nM
Synonyms	MDV3100-d3, MDV3100 D3, Deutenzalutamide-d3

Chemical Properties

Molecular Weight	467.45
Formula	C₂₁H₁₆F₄N₄O₂S
Cas No.	1443331-82-5
Smiles	S=C1N(C(C)(C)C(=O)N1C2=CC(C(F)(F)F)=C(C#N)C=C2)C3=CC(F)=C(C(NC([2H])([2H])[2H])=O)C=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (42.79 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1393 mL	10.6963 mL	21.3927 mL	106.9633 mL
5 mM	0.4279 mL	2.1393 mL	4.2785 mL	21.3927 mL
10 mM	0.2139 mL	1.0696 mL	2.1393 mL	10.6963 mL
20 mM	0.1070 mL	0.5348 mL	1.0696 mL	5.3482 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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