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Anticancer agent 71

Catalog No. T62044 CAS 2453228-45-8

Anticancer agent 71 (Compound 4b) is a potent anticancer agent. Anticancer agent 71 arrests cell cycle at G2/M phase. Anticancer agent 71 induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels.

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Anticancer agent 71, CAS 2453228-45-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description

In vitro

Anticancer agent 71 (Compound 4b), administered at concentrations ranging from 0.1 to 50 μM for 24 hours, significantly enhances cytotoxic effects and demonstrates robust antitumor potential in SW480 and PC3 cells [1]. This compound, at a specific dose of 11.08 μM applied to SW480 cells for the same duration, notably induces G2/M phase arrest [1] and triggers apoptosis. The apoptosis mechanism involves the upregulation of Bax and Ikb-α, along with cleaved PARP, and the downregulation of Bcl-2 expression [1]. Through cell cytotoxicity assays, it was determined that agent 71 inhibits cell viability with IC 50 values of 11.08 μM for SW480 cells and 17.39 μM for PC3 cells. Additionally, cell cycle analysis revealed a 45.3% increase in the G2/M phase population in SW480 cells. Apoptosis analysis recorded early and late apoptosis rates at 5.69% and 3.52%, respectively. Western blot analysis confirmed these findings by showing a decrease in Bcl-2 expression and an increase in Bax expression, highlighting the compound's ability to effectively promote apoptosis in cancer cells [1].

Molecular Weight	407.78
Formula	C18H13ClF3N5O
CAS No.	2453228-45-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Anticancer agent 71 2453228-45-8 inhibitor inhibit

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