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thermospermine

Name: thermospermine
Brand: TargetMol
SKU: T60066
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T60066Cas No. 70862-11-2

Alias N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine, 1,12-Diamino-4,8-diazadodecane

Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation and can enhance the translation of SAC51 and SACL1 in Arabidopsis thaliana. Thermospermine is also used in studies as a plant growth regulator and for controlling wood biomass production.

thermospermine

🥰Excellent

Purity: 99.95%

Catalog No. T60066Alias N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine, 1,12-Diamino-4,8-diazadodecaneCas No. 70862-11-2

Pack Size	Price	Availability
1 mg	$146	In Stock
5 mg	$363	In Stock
10 mg	$538	In Stock
25 mg	$818	In Stock
50 mg	$1,130	In Stock
100 mg	$1,530	In Stock
200 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$328	In Stock

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Purity:99.95%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation and can enhance the translation of SAC51 and SACL1 in Arabidopsis thaliana. Thermospermine is also used in studies as a plant growth regulator and for controlling wood biomass production.
In vitro	The mutant defective in the biosynthesis of thermospermine, ACL5, shows a dwarf phenotype with excess xylem vessels in Arabidopsis thaliana. Exogenous supply of thermospermine remarkably represses xylem differentiation in the root of seedlings. Rice showed up-regulation of phloem-expressed genes, OsHB5 and OsYSL16, by one-day treatment with thermospermine.Expression of OsPAO2 and OsPAO6, encoding extracellular polyamine oxidase whose orthologs are not present in Arabidopsis, was induced by both thermospermine and spermine[3].
Synonyms	N'-[3-(3-aminopropylamino)propyl]butane-1,4-diamine, 1,12-Diamino-4,8-diazadodecane

Chemical Properties

Molecular Weight	202.34
Formula	C₁₀H₂₆N₄
Cas No.	70862-11-2
Smiles	NCCCCNCCCNCCCN
Color	Pink
Appearance	Liquid

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (271.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9422 mL	24.7109 mL	49.4218 mL	247.1088 mL
5 mM	0.9884 mL	4.9422 mL	9.8844 mL	49.4218 mL
10 mM	0.4942 mL	2.4711 mL	4.9422 mL	24.7109 mL
20 mM	0.2471 mL	1.2355 mL	2.4711 mL	12.3554 mL
50 mM	0.0988 mL	0.4942 mL	0.9884 mL	4.9422 mL
100 mM	0.0494 mL	0.2471 mL	0.4942 mL	2.4711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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