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Anti-TLR4 Antibody (1M331)
Catalog No. TMAB-13571 Copy Product Info
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Anti-TLR4 Antibody (1M331) is a Mouse antibody targeting TLR4. Anti-TLR4 Antibody (1M331) can be used in WB.
Anti-TLR4 Antibody (1M331)
Copy Product Info🥰Excellent
Catalog No. TMAB-13571
Anti-TLR4 Antibody (1M331) is a Mouse antibody targeting TLR4. Anti-TLR4 Antibody (1M331) can be used in WB.
Anti-TLR4 Antibody
(1M331)
(1M331)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $297 | 7-10 days | 7-10 days | |
| 100 μL | $470 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TLR4 Antibody (1M331) is a Mouse antibody targeting TLR4. Anti-TLR4 Antibody (1M331) can be used in WB. |
| Ig Type | IgG1, k |
| Clone | 1M331 |
| Reactivity | Mouse,Human,Rat |
| Verified Activity | 1. 25 ug total protein per lane of various lysates (see on figure) probed with TLR4 monoclonal antibody, unconjugated (TMAB-13571) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. 2. THP-1 (H) cells were treated with or without TPA (80 nM) for 18 h, incubated in fresh medium for 48 h, and LPS (5 μg/mL) for 18 h, 25 μg total protein per lane of cell lysates (see on figure) probed with TLR4 monoclonal antibody, unconjugated (TMAB-13571) at 1: 1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min. |
| Application | |
| Recommended Dose | WB=1:500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The Toll-like receptor 4 by activating natural immunity, specific immune response involved in the start-up, Toll-like receptor 4 as an important signal transduction transmembrane receptor involved in the toxin-induced inflammation in the pathological process, its mechanisms of control On a growing concern. all regions were either double-stranded or sequenced with an alternatechemistry or covered by high quality data(i.e., phred quality >=30); an attempt was made to resolve all sequencing problems, such as compressions and repeats; all regions were covered by at least one subclone; and the assembly was confirmed by restriction digest, except on the rare occasion of the clone being a YAC. The following abbreviations are used to associate primary accession numbers given in the feature table with their source databases: Em:, EMBL; Sw:, SWISSPROT; Tr:, TREMBL; Wp:, WORMPEP; Information on the WORMPEP database can be found at. TLR-4 plays an important role in microvascular leakage and leukocyte adhesion under the inflammatory condition associated with nonseptic thermal injury. |
| Immunogen | KLH conjugated synthetic peptide: mouse TLR4 |
| Antigen Species | Mouse |
| Gene Name | TLR4 |
| Gene ID | |
| Protein Name | Toll-like receptor 4 |
| Uniprot ID | |
| Function | Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific. |
| Molecular Weight | Theoretical: 90 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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