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Anti-IL-1R1 Antibody (8T715)

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Catalog No. TMAY-00311
Alias interleukin 1 receptor, type I

Anti-IL-1R1 Antibody (8T715) is a Mouse antibody targeting IL-1R1. Anti-IL-1R1 Antibody (8T715) can be used in ELISA(Cap).

Anti-IL-1R1 Antibody (8T715)

Anti-IL-1R1 Antibody (8T715)

😃Good
Catalog No. TMAY-00311Alias interleukin 1 receptor, type I
Anti-IL-1R1 Antibody (8T715) is a Mouse antibody targeting IL-1R1. Anti-IL-1R1 Antibody (8T715) can be used in ELISA(Cap).
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20 μL$69 7-10 days
100 μL$199 7-10 days
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Product Introduction

Bioactivity
Description
Anti-IL-1R1 Antibody (8T715) is a Mouse antibody targeting IL-1R1. Anti-IL-1R1 Antibody (8T715) can be used in ELISA(Cap).
Aliasinterleukin 1 receptor, type I
Ig Type
Monoclonal Mouse IgG2a
Clone
8T715
Reactivity
Human
Application
ELISA(Cap)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IL1R1 / IL-1R1 / IL-1 RI (rh IL1R1 / IL-1R1 / IL-1 RI; TMPY-01048; NP_000868.1; Met1-Thr332). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundInterleukin 1 receptor, type I (IL-1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL-1R1/CD121a is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokines induced immune and inflammatory responses. This protein has been characterized by pharmacological and molecular techniques in the mouse brain. The spindle-shaped astrocytes enclose the wound, separating the healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1β activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1type 1 receptor antagonist protein (IL-1ra) blocks IL-1β induced effects. In the spleen, a slight increase in IL-1R ACP and IL-1R1 was observed during the first hours following LPS stimulation. In conclusion, IL-1R AcP mRNA is expressed in the brain and in other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human IL1R1 / IL-1R1 / IL-1 RI Protein (TMPY-01048)
Antigen Species
Human
Biology Area
Neuroinflammation
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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