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JNT-517

Name: JNT-517
Brand: TargetMol
SKU: T82004
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T82004Cas No. 2837993-05-0

Alias Repinatrabit, JNT517, JNT 517

JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).

JNT-517

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Purity: 99.82%

Catalog No. T82004Alias Repinatrabit, JNT517, JNT 517Cas No. 2837993-05-0

JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	-	In Stock
5 mg	$162	-	In Stock
10 mg	$247	-	In Stock
25 mg	$397	-	In Stock
50 mg	$569	-	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$177	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).
Targets&IC50	SLC6A19 (human):47 nM
Synonyms	Repinatrabit, JNT517, JNT 517

Chemical Properties

Molecular Weight	418.39
Formula	C₁₈H₂₂F₄N₄O₃
Cas No.	2837993-05-0
Smiles	N(C(NCC1=C(F)C=C(OC(F)(F)F)C=C1)=O)([C@H]2CN(C(N)=O)CCC2)C3CC3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (191.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc