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JNT-517

Name: JNT-517
Brand: TargetMol
SKU: T82004
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T82004Cas No. 2837993-05-0

Alias Repinatrabit, JNT517, JNT 517

JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).

JNT-517

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Purity: 99.82%

Catalog No. T82004Alias Repinatrabit, JNT517, JNT 517Cas No. 2837993-05-0

JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	-	In Stock
5 mg	$162	-	In Stock
10 mg	$247	-	In Stock
25 mg	$397	-	In Stock
50 mg	$569	-	In Stock
100 mg	$786	-	In Stock
1 mL x 10 mM (in DMSO)	$177	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	JNT-517 (Example 352) is an orally active and selective allosteric inhibitor of SLC6A19 (IC50 = 47 nM) for studying phenylketonuria (PKU).
Targets&IC50	SLC6A19 (human):47 nM
Synonyms	Repinatrabit, JNT517, JNT 517

Chemical Properties

Molecular Weight	418.39
Formula	C₁₈H₂₂F₄N₄O₃
Cas No.	2837993-05-0
Smiles	N(C(NCC1=C(F)C=C(OC(F)(F)F)C=C1)=O)([C@H]2CN(C(N)=O)CCC2)C3CC3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (191.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3901 mL	11.9506 mL	23.9011 mL	119.5057 mL
5 mM	0.4780 mL	2.3901 mL	4.7802 mL	23.9011 mL
10 mM	0.2390 mL	1.1951 mL	2.3901 mL	11.9506 mL
20 mM	0.1195 mL	0.5975 mL	1.1951 mL	5.9753 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3901 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1951 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc