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HDL-16
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Catalog No. T86565Cas No. 2373280-36-3
Alias HD16
HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.
HDL-16
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Purity: 97.58%
Catalog No. T86565Alias HD16Cas No. 2373280-36-3
HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $77 | In Stock | In Stock | |
| 25 mg | $156 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
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Purity:97.58%
Appearance:Solid
Color:Yellow
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | HDL-16 is a highly effective P2Y14R antagonist with anti-colitis effects, targeting P2Y14R in intestinal epithelial cells to alleviate ulcerative colitis. |
| Targets&IC50 | P2Y14 receptor:0.3095 nM |
| In vitro | HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 forms hydrogen bonds with Tyr102 residues through the N atom on its benzooxazole ring and its amine group with His184 residues of P2Y14R. At a concentration of 10μM, HDL-16 showed very low cytotoxicity to HT-29 cells. In addition, HDL-16 effectively inhibited HT-29 cells under specific conditions (20ng/mL TNF-α, 20μM z-VAD-fmk and Smac analog BV6, 2μM; Necrotic apoptosis lasting 8 hours). |
| In vivo | HDL-16 significantly inhibited colitis symptoms in mice and maintained the integrity of the intestinal barrier in mice . The experimental animal models were 7-8 week-old male WT mice with P2Y 14 R fl/ FLvil-CRE (P2Y 14 R ∆IEC), P2Y 14 R fl/fl Lyz2-cre and C57BL/6 J background . The dose is 10 μM or 20 μM and is administered rectum daily for 6 days. The results showed that the weight loss and disease activity index (DAI) of mice in the high-dose group were significantly lower than those exposed to 3% w/v, 36-50 kDa DSS (7 days after drinking water). High dose improved the inflammatory infiltration and tissue damage induced by DSS, and significantly inhibited the cell necrosis of intestinal epithelial cells in DSS treated mice.[1] |
| Synonyms | HD16 |
| Molecular Weight | 303.15 |
| Formula | C14H11BrN2O |
| Cas No. | 2373280-36-3 |
| Smiles | BrC1=CC=C(C=C1)NCC2=NC=3C=CC=CC3O2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (263.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 3.3 mg/mL (10.89 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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