Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
Description | MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1). |
In vitro | MT1 (100 nM, 24 h) notably initiates apoptosis in MV4;11 cells through caspase-3 and PARP pathways as demonstrated by significant caspase-3 and PARP cleavage observed in Western Blot Analysis[1]. This effect was consistent at a concentration of 100 nM over a 24-hour incubation period. |
In vivo | MT1, administered intraperitoneally at doses of 44.2 and 22.1 μmol/kg daily for 14 days, significantly delayed the progression of leukemia in mice (Mus musculus) in comparison to the control, JQ1. Additionally, MT1 demonstrated a terminal half-life (t 1/2) of 2.70 hours in mice. In the context of leukemia xenograft models, this regimen markedly reduced the leukemic burden over the study period when compared to either the vehicle or JQ1. |
Molecular Weight | 1134.2 |
Formula | C54H66Cl2N10O9S2 |
CAS No. | 2060573-82-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MT1 2060573-82-0 MT 1 MT-1 inhibitor inhibit