Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 8-10 weeks | $ 1,520.00 | |
50 mg | 8-10 weeks | $ 1,980.00 | |
100 mg | 8-10 weeks | $ 2,500.00 |
Description | AAK1-IN-3 is a quinoline analogue that can be used in the research of neuropathic pain. AAK1-IN-3 is a brain-penetrant inhibitor of adaptor protein 2-associated kinase 1 (AAK1) (IC 50 = 11 nM) [1]. |
In vitro | AAK1-IN-3 (compound (R)-31) is a brain-penetrant kinase inhibitor exhibiting a blood/plasma (B/P) ratio of 1.3 [1]. It effectively inhibits AAK1 in HEK293 cells, demonstrating an IC50 value of 108 nM [1]. |
In vivo | AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; single dose) reduces μ2 phosphorylation by 46% in C57BL6 mice [1]. |
Molecular Weight | 316.4 |
Formula | C20H20N4 |
CAS No. | 1802703-20-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AAK1-IN-3 1802703-20-3 inhibitor inhibit