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CZL80
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Catalog No. T86155Cas No. 313482-91-6
Alias CZL-80, CZL 80
CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
CZL80
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Purity: 99.48%
Catalog No. T86155Alias CZL-80, CZL 80Cas No. 313482-91-6
CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | - | In Stock | |
| 5 mg | $56 | - | In Stock | |
| 10 mg | $91 | - | In Stock | |
| 25 mg | $183 | - | In Stock | |
| 50 mg | $297 | - | In Stock | |
| 100 mg | $475 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $62 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.48%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology. |
| Targets&IC50 | Caspase-1:0.01 μM |
| In vivo | CZL80 (10, 30 mg/kg/day, intraperitoneal injection, for 7 days) ameliorated motor dysfunction in C57BL/6 mice and Caspase-1⁻/⁻ mice after photothrombotic stroke [2]. CZL80 (0.0075, 0.075, 0.75, and 7.5 mg/kg, intravenous injection, administered every other day) reduced epileptic seizure incidence in a dose-dependent manner, prolonged epileptic seizure latency, and increased the induction threshold of high-grade fever febrile convulsions in Casp1⁻/⁻ mice [1]. |
| Synonyms | CZL-80, CZL 80 |
| Molecular Weight | 366.39 |
| Formula | C19H14N2O4S |
| Cas No. | 313482-91-6 |
| Smiles | O=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=C(C2)NC(=O)C=3SC=CC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ≥ 160 mg/mL, Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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