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CZL80
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Catalog No. T86155Cas No. 313482-91-6
Alias CZL-80, CZL 80
CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
CZL80
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Purity: 99.48%
Catalog No. T86155Alias CZL-80, CZL 80Cas No. 313482-91-6
CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | - | In Stock | |
| 5 mg | $56 | - | In Stock | |
| 10 mg | $91 | - | In Stock | |
| 25 mg | $183 | - | In Stock | |
| 50 mg | $297 | - | In Stock | |
| 100 mg | $475 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $62 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.48%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CZL80 is a brain-penetrant caspase-1 inhibitor with an IC50 of 0.01 μM that is used to study febrile seizures and subsequent epileptogenic susceptibility. CZL80 reduces neuronal excitability, decreases the incidence of febrile seizure generation at 7.5 mg/kg intravenously, and mitigates long-term neurological dysfunction following photothrombosis, establishing CZL80 as a valuable tool for neuroinflammation, seizure biology, and stroke-induced pathology. |
| Targets&IC50 | Caspase-1:0.01 μM |
| In vivo | CZL80 (10, 30 mg/kg/day, intraperitoneal injection, for 7 days) ameliorated motor dysfunction in C57BL/6 mice and Caspase-1⁻/⁻ mice after photothrombotic stroke [2]. CZL80 (0.0075, 0.075, 0.75, and 7.5 mg/kg, intravenous injection, administered every other day) reduced epileptic seizure incidence in a dose-dependent manner, prolonged epileptic seizure latency, and increased the induction threshold of high-grade fever febrile convulsions in Casp1⁻/⁻ mice [1]. |
| Synonyms | CZL-80, CZL 80 |
| Molecular Weight | 366.39 |
| Formula | C19H14N2O4S |
| Cas No. | 313482-91-6 |
| Smiles | O=C(O)C=1C=CC=C(C1)NC(=O)C=2C=CC=C(C2)NC(=O)C=3SC=CC3 |
| Color | Yellow |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: ≥ 160 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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