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Proglumide

Name: Proglumide
Brand: TargetMol
SKU: T1052
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1052Cas No. 6620-60-6

Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.

Proglumide

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Purity: 99.45%

Catalog No. T1052Cas No. 6620-60-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$47	In Stock	In Stock
100 mg	$89	In Stock	In Stock
200 mg	$121	In Stock	In Stock
500 mg	$196	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$52	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.45%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Proglumide AI Summary

Proglumide demonstrates a wide range of bioactivities across various biological targets. It shows significant inhibitory activity against the binding of [125I](Nle11)-HG-13 to the Histamine H2 receptor with an IC50 value of 2,500,000 nM and effectively inhibits gastrin-stimulated acid secretion in an in situ perfused rat stomach with an ED50 of 350.0 µmol/kg. Additionally, it displays IC50 values of 250,000 nM for CCK-33 binding to rat pancreas and other specific receptor bindings. It inhibits multiple enzymes such as Tyrosyl-DNA Phosphodiesterase (IC50: 63,095.7 nM) and Endonuclease IV (IC50: 14,125.4 nM), indicating its potential as an enzymatic inhibitor. Proglumide also affects viral activity, showing considerable inhibition against Lassa and Marburg viruses and blocking Ebola virus entry. Despite these effects, it exhibits low antiviral activity against SARS-CoV-2 with an inhibition index of 0.09912 and moderate inhibition of the human HDAC6 enzyme. The compound impacts various physiological parameters related to liver and kidney function, blood electrolytes, cholesterol levels, enzyme activities, and blood cell counts. Lastly, Proglumide displays binding affinity and modulating activities across several receptors and transporters, reaffirming its broad-spectrum bioactivity. Further research is needed to fully understand its mechanisms and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	334.41
Formula	C₁₈H₂₆N₂O₄
Cas No.	6620-60-6
Smiles	CCCN(CCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC=CC=C1
Relative Density.	1.136 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (164.47 mM)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9903 mL	14.9517 mL	29.9034 mL	149.5171 mL
5 mM	0.5981 mL	2.9903 mL	5.9807 mL	29.9034 mL
10 mM	0.2990 mL	1.4952 mL	2.9903 mL	14.9517 mL
20 mM	0.1495 mL	0.7476 mL	1.4952 mL	7.4759 mL
50 mM	0.0598 mL	0.2990 mL	0.5981 mL	2.9903 mL
100 mM	0.0299 mL	0.1495 mL	0.2990 mL	1.4952 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc