AGN 192836

Name: AGN 192836
Brand: TargetMol
SKU: T10264
Rating: 4.5 (1 reviews)

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Catalog No. T10264Cas No. 171102-29-7

AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7 nM, 41 nM, and 6.6 nM for the α2A, α2B, and α2C receptors, respectively.

AGN 192836

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Catalog No. T10264Cas No. 171102-29-7

AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7 nM, 41 nM, and 6.6 nM for the α2A, α2B, and α2C receptors, respectively.

Pack Size	Price	Availability
25 mg	$1,080	8-10 weeks
50 mg	$1,410	8-10 weeks
100 mg	$2,220	8-10 weeks

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Product Introduction

Bioactivity

Description	AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7 nM, 41 nM, and 6.6 nM for the α2A, α2B, and α2C receptors, respectively.
Targets&IC50	α2A:（EC50）8.7 nM , α2B: 41 nM , α2C: 6.6 nM
In vitro	AGN 192836 is 1200-fold selective for the α2A-receptor relative to the α1-receptor, 50-fold selective for the α2A-receptor relative to the α2B-receptor, and 10-fold selective for the α2Areceptor relative to the α2C-receptor.
In vivo	AGN 192836 demonstrates equivalent efficacy to brimonidine in lowering intraocular pressure when topically applied to rabbits and surpasses brimonidine's effectiveness in reducing blood pressure through intravenous administration in monkeys.

Chemical Properties

Molecular Weight	231.25
Formula	C₁₂H₁₃N₃O₂
Cas No.	171102-29-7
Relative Density.	1.342 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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