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Lagociclovir

Name: Lagociclovir
Brand: TargetMol
SKU: T15704
Price: 310 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15704Cas No. 92562-88-4

Alias MIV-210

Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.

Lagociclovir

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Purity: 99.74%

Catalog No. T15704Alias MIV-210Cas No. 92562-88-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$310	In Stock	In Stock
5 mg	$757	In Stock	In Stock
10 mg	$1,060	-	In Stock
25 mg	$1,580	-	In Stock
50 mg	$2,130	-	In Stock
1 mL x 10 mM (in DMSO)	$719	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.74%

ee:100%

Appearance:Solid

Color:White

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COA CSFC FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	Lagociclovir (MIV-210), a nucleoside analogue, is an antiviral compound available for the treatment of HBV82 that inhibits the replication of wild-type hepatitis B virus (HBV) in human hepatocellular carcinoma cell lines that permanently express HBV.
Targets&IC50	HBV (WT):9 μM, HBV (3TC-R):8 μM, HBV (3TC+PMEA-R):15 μM, PMEA-R (HBV):13 μM
In vitro	Lagociclovir (FLG) (6 days) demonstrated inhibitory activity against 3TC-R HBV, wt HBV, PMEA-R HBV, and 3TC+PMEA-R HBV in transiently transfected Huh7 cells, with IC50s of 8 ± 3.8, 9 ± 2.5, 13 ± 3.4, and 15 ± 6.8 μM, respectively [1]. Lagociclovir (0-100 μM; 6 days) also inhibits the replication of HBV wild-type and drug-resistant mutants in transiently transfected Huh7 cells [2].
In vivo	Anti-HBV compound Oral administration of MIV-210 (20 or 60 mg/kg; body weight/day) induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. MIV-210 at 20 or 60 mg/kg/day reduced the liver WHV DNA load 200- to 2,500-fold from pretreatment levels and, importantly, led to a 2.0 log10 drop in the hepatic content of WHV covalently closed circular DNA. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 weeks of treatment, and a dose of 5 mg/kg/day was sufficient to maintain this antiviral effect during the following 6-week period.[1]
Synonyms	MIV-210

Chemical Properties

Molecular Weight	269.23
Formula	C₁₀H₁₂FN₅O₃
Cas No.	92562-88-4
Smiles	O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](F)C3)NC(N)=N1
Relative Density.	2.01g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (92.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7143 mL	18.5715 mL	37.1430 mL	185.7148 mL
5 mM	0.7429 mL	3.7143 mL	7.4286 mL	37.1430 mL
10 mM	0.3714 mL	1.8571 mL	3.7143 mL	18.5715 mL
20 mM	0.1857 mL	0.9286 mL	1.8571 mL	9.2857 mL
50 mM	0.0743 mL	0.3714 mL	0.7429 mL	3.7143 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc