Anti-MICB Antibody is a humanized monoclonal antibody targeting MHC class I polypeptide-related sequence B (MICB). MICB is a critical ligand for the activating receptor NKG2D expressed on NK cells and CD8+ T cells. Tumor cells often evade immune surveillance by proteolytically shedding MICB via proteases (e.g., ADAM10/17), leading to reduced surface ligand density. This antibody typically binds to the α3 domain of MICB, specifically inhibiting its proteolytic shedding and stabilizing MICB expression on the tumor cell surface. This process restores NKG2D-mediated immune recognition and enhances the cytotoxic activity of NK cells and T cells against tumors, serving as a vital tool for researching tumor immune evasion mechanisms and developing novel immunotherapies.