Shopping Cart

Your shopping cart is currently empty

Pipequaline hydrochloride

Name: Pipequaline hydrochloride
Brand: TargetMol
SKU: T4688
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T4688Cas No. 80221-58-5

Alias PK-8165 hydrochloride

Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict and anticonvulsant quinoline derivative and an anxiolytic drug that was never marketed. It possesses a novel chemical structure, not closely related to other drugs of this type, with a pharmacological profile similar to benzodiazepines but predominantly anxiolytic, exhibiting minimal sedative, amnestic, or anticonvulsant effects, thus classified as a nonbenzodiazepine anxiolytic.

Pipequaline hydrochloride

Copy Product Info

😃Good

Purity: 99.78%

Catalog No. T4688Alias PK-8165 hydrochlorideCas No. 80221-58-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$90	In Stock	In Stock
10 mg	$132	In Stock	In Stock
25 mg	$228	In Stock	In Stock
50 mg	$360	In Stock	In Stock
100 mg	$540	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.78%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Pipequaline hydrochloride (PK-8165 hydrochloride) is an anticonflict and anticonvulsant quinoline derivative and an anxiolytic drug that was never marketed. It possesses a novel chemical structure, not closely related to other drugs of this type, with a pharmacological profile similar to benzodiazepines but predominantly anxiolytic, exhibiting minimal sedative, amnestic, or anticonvulsant effects, thus classified as a nonbenzodiazepine anxiolytic.
In vitro	Pipequaline is extensively bound to plasma proteins: i.e. human serum albumin (HSA), alpha-1-acid glycoprotein (AAG), lipoproteins and blood cells, mainly erythrocytes[1].
In vivo	Intravenously administered pipequaline exerts a partial suppression of activations by kainate, glutamate and acetylcholine. Microiontophoretic applications of pipequaline reduces the neuronal activation by kainate[2]. Pipequaline produces dose-related decreases in motor activity. Pipequaline produces significant dose-related decreases in the number of head-dips made[3].
Animal Research	Rats: Pipequaline is dissolved in water to give injection volumes of 2 mL/kg. Rats are injected with 5, 10, and 50 mg/kg pipequaline. Infrared cells in the walls of the box provided automated measures of locomotor activity and rearing, respectively[3].
Synonyms	PK-8165 hydrochloride

Chemical Properties

Molecular Weight	352.9
Formula	C₂₂H₂₅ClN₂
Cas No.	80221-58-5
Smiles	Cl.C(Cc1cc(nc2ccccc12)-c1ccccc1)C1CCNCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: >30 mg/mL (94.8 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8337 mL	14.1683 mL	28.3366 mL	141.6832 mL
5 mM	0.5667 mL	2.8337 mL	5.6673 mL	28.3366 mL
10 mM	0.2834 mL	1.4168 mL	2.8337 mL	14.1683 mL
20 mM	0.1417 mL	0.7084 mL	1.4168 mL	7.0842 mL
50 mM	0.0567 mL	0.2834 mL	0.5667 mL	2.8337 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc