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DO-264

Name: DO-264
Brand: TargetMol
SKU: T11069
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11069Cas No. 2301866-59-9

DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis.

DO-264

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Purity: 99.95%

Catalog No. T11069Cas No. 2301866-59-9

DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	-	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	-	In Stock
25 mg	$438	-	In Stock
50 mg	$745	6-8 weeks	6-8 weeks
100 mg	$1,050	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$148	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.95%

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COA LCMS

Product Introduction

Bioactivity

Description	DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis.
Targets&IC50	ABHD12:11 nM
In vitro	DO-264 elevated the lyso-PS and 20:4 PS content of primary human macrophages[1].
In vivo	Mice treated with DO-264 exhibited a dose-dependent increase in brain lyso-PS and 20:4 PS content, which qualitatively resembled changes observed in ABHD12(-/-) mice. Additionally, both ABHD12(-/-) and DO-264-treated mice displayed exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death.[1].

Chemical Properties

Molecular Weight	558.4
Formula	C₂₃H₂₀Cl₂F₃N₅O₂S
Cas No.	2301866-59-9
Smiles	FC(F)(F)Oc1ccc(Oc2ccnc(N3CCC(CC3)NC(=S)Nc3cccnc3)c2Cl)c(Cl)c1
Relative Density.	1.52 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (143.27 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7908 mL	8.9542 mL	17.9083 mL	89.5415 mL
5 mM	0.3582 mL	1.7908 mL	3.5817 mL	17.9083 mL
10 mM	0.1791 mL	0.8954 mL	1.7908 mL	8.9542 mL
20 mM	0.0895 mL	0.4477 mL	0.8954 mL	4.4771 mL
50 mM	0.0358 mL	0.1791 mL	0.3582 mL	1.7908 mL
100 mM	0.0179 mL	0.0895 mL	0.1791 mL	0.8954 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc