NRG1 beta 1 Protein, Human, Recombinant

Catalog No. TMPY-03010 Copy Product Info

NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.

NRG1 beta 1 Protein, Human, Recombinant

Catalog No. TMPY-03010

Copy Product Info

NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.

Pack Size	Price	USA Stock	Global Stock
5 μg	$54	-	In Stock
10 μg	$88	-	In Stock
20 μg	$138	-	In Stock
50 μg	$276	-	In Stock
100 μg	$535	7-10 days	7-10 days
200 μg	$815	7-10 days	7-10 days
500 μg	$1,680	7-10 days	7-10 days
1 mg	$3,480	7-10 days	7-10 days

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For In stock only · Estimated delivery:USA Stock (1-2 days) Global Stock (5-7 days)

For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	Measured in a cell proliferation assay using MCF-7 cells. The ED50 for this effect is typically 2-10 ng/mL.
Description	NRG1 beta 1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 26.8 kDa and the accession number is Q02297-6.
Species	Human
Expression System	HEK293 Cells
Tag	Tag Free
Accession Number	Q02297-6
Synonyms	SMDF,NRG1-IT2,NRG1 β1,Neuregulin 1,NDF,MSTP131,MST131,HRGA,HRG1,HRG,HGL,Heregulin beta-1,GGF2,GGF,ARIA
Construction	A DNA sequence encoding the N-terminal fragment (Ser 2-Lys 246) of human NRG1 isoform beta1 (Q02297-6) was expressed. Predicted N terminal: Ser 2
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	26.8 kDa (predicted); 47.7 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.15 mg/mL. Reconstitution conditions may vary depending on the lot.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Research Background	Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.