TP-238 hydrochloride

Name: TP-238 hydrochloride
Brand: TargetMol
SKU: T40055
Rating: 4.5 (1 reviews)

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Catalog No. T40055Cas No. 2415263-05-5

TP-238 hydrochloride is a highly potent and selective dual CECR2/BPTF probe, demonstrating IC50 values of 30 nM and 350 nM, respectively. It additionally exerts inhibitory effects on BRD9, with a pIC50 value of 5.9, while displaying lower activity against 338 other kinases.

TP-238 hydrochloride

🥰Excellent

Catalog No. T40055Cas No. 2415263-05-5

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Product Introduction

Bioactivity

Description	TP-238 hydrochloride is a highly potent and selective dual CECR2/BPTF probe, demonstrating IC50 values of 30 nM and 350 nM, respectively. It additionally exerts inhibitory effects on BRD9, with a pIC50 value of 5.9, while displaying lower activity against 338 other kinases.
Targets&IC50	BRD9:5.9 (pIC50), CECR2:30 nM, CECR2:7.5 (pIC50), CECR2:10 nM (Kd), BPTF:6.5 (pIC50), BPTF:120 nM (Kd), BPTF:350 nM
In vitro	TP-238 exhibits specificity and potency towards CECR2 and BPTF, with an on-target biochemical activity measured at 10-30 nM for CECR2 and 100-350 nM for BPTF. In an Alpha screen assay, TP-238 demonstrates effectiveness, evidencing a pIC50 of 7.5 for CECR2 and 6.5 for BPTF. Further analysis using Isothermal Titration Calorimetry (ITC) reveals TP-238 binds with a dissociation constant (Kd) of 10 nM for CECR2 and 120 nM for BPTF[1][2].

Chemical Properties

Molecular Weight	495.04
Formula	C₂₂H₃₁ClN₆O₃S
Cas No.	2415263-05-5
Smiles	Cl.CN(C)CCCOc1ccc(cc1)-c1cc(NCCCn2cccn2)nc(n1)S(C)(=O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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