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PF-670462

Name: PF-670462
Brand: TargetMol
SKU: T3073
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3073Cas No. 950912-80-8

Alias PF670462

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.

PF-670462

🥰Excellent

Purity: 99.72%

Catalog No. T3073Alias PF670462Cas No. 950912-80-8

PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$42	In Stock	In Stock
5 mg	$68	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	$215	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$590	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$74	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.72%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
Targets&IC50	CK1ε:7.7 ± 2.2 nM
Synonyms	PF670462

Chemical Properties

Molecular Weight	410.32
Formula	C₁₉H₂₂Cl₂FN₅
Cas No.	950912-80-8
Smiles	Cl.Cl.Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (134.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (6.09 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4371 mL	12.1856 mL	24.3712 mL	121.8561 mL
5 mM	0.4874 mL	2.4371 mL	4.8742 mL	24.3712 mL
10 mM	0.2437 mL	1.2186 mL	2.4371 mL	12.1856 mL
20 mM	0.1219 mL	0.6093 mL	1.2186 mL	6.0928 mL
50 mM	0.0487 mL	0.2437 mL	0.4874 mL	2.4371 mL
100 mM	0.0244 mL	0.1219 mL	0.2437 mL	1.2186 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc